Immune response profiling identifies autoantibodies specific to Moyamoya patients

Moyamoya Disease is a rare, devastating cerebrovascular disorder characterized by stenosis/occlusion of supraclinoid internal carotid arteries and development of fragile collateral vessels. Moyamoya Disease is typically diagnosed by angiography after clinical presentation of cerebral hemorrhage or i...

Full description

Saved in:
Bibliographic Details
Published in:Orphanet journal of rare diseases 2013-03, Vol.8 (1), p.45-45, Article 45
Main Authors: Sigdel, Tara K, Shoemaker, Lorelei D, Chen, Rong, Li, Li, Butte, Atul J, Sarwal, Minnie M, Steinberg, Gary K
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Aged
Antibody Specificity
Arrays
Autoantibodies
Autoantibodies - blood
Autoimmune diseases
Autoimmunity
Cell cycle
Cell division
Cerebral Angiography
Cerebrovascular Disorders - diagnostic imaging
Cerebrovascular Disorders - immunology
Cerebrovascular Disorders - physiopathology
Computational Biology - methods
Demography
Deoxyribonucleic acid
Disease
DNA
DNA repair
Down syndrome
Female
Humans
Immune response
Immunoglobulin G - blood
Information management
Male
Medical research
Middle Aged
Moyamoya disease
Moyamoya Disease - diagnostic imaging
Moyamoya Disease - immunology
Moyamoya Disease - physiopathology
Mutation
Nervous system diseases
Neurosurgery
Patients
Pediatrics
Physiological aspects
Protein Array Analysis - methods
Protein Processing, Post-Translational
Proteins
Rare diseases
Single nucleotide polymorphisms
Stem cells
Veins & arteries
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Moyamoya Disease is a rare, devastating cerebrovascular disorder characterized by stenosis/occlusion of supraclinoid internal carotid arteries and development of fragile collateral vessels. Moyamoya Disease is typically diagnosed by angiography after clinical presentation of cerebral hemorrhage or ischemia. Despite unclear etiology, previous reports suggest there may be an immunological component. To explore the role of autoimmunity in moyamoya disease, we used high-density protein arrays to profile IgG autoantibodies from the sera of angiographically-diagnosed Moyamoya Disease patients and compared these to healthy controls. Protein array data analysis followed by bioinformatics analysis yielded a number of auto-antibodies which were further validated by ELISA for an independent group of MMD patients (n = 59) and control patients with other cerebrovascular diseases including carotid occlusion, carotid stenosis and arteriovenous malformation. We identified 165 significantly (p 
ISSN:1750-1172
1750-1172
DOI:10.1186/1750-1172-8-45