Base J: Blocking RNA Polymerase’s Way

How do cells stop transcribing RNA Polymerase II to promote proper gene expression and prevent transcriptional havoc in the genome? A uniquely modified DNA base in Leishmania blocks RNA Polymerase II and suggests an interesting new model for transcription termination.

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Bibliographic Details
Published in:Current biology 2012-11, Vol.22 (22), p.R960-R962
Main Authors: Hazelbaker, Dane Z., Buratowski, Stephen
Format: Article
Language:English
Online Access:Get full text
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Description
Summary:How do cells stop transcribing RNA Polymerase II to promote proper gene expression and prevent transcriptional havoc in the genome? A uniquely modified DNA base in Leishmania blocks RNA Polymerase II and suggests an interesting new model for transcription termination.
ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2012.10.010