Long-term follow-up of children conceived through assisted reproductive technology

Children conceived via assisted reproductive technologies （ART） are nowadays a substantial proportion of the population. It is important to follow up these children and evaluate whether they have elevated health risks com- pared to naturally conceived （NC） children. In recent years there has been a...

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Bibliographic Details
Published in:Journal of Zhejiang University. B. Science 2013-05, Vol.14 (5), p.359-371
Main Authors: Lu, Yue-hong, Wang, Ning, Jin, Fan
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Child
Child, Preschool
Comorbidity
Congenital Abnormalities - epidemiology
Developmental Disabilities - epidemiology
Female
Genetic Predisposition to Disease - genetics
Humans
Incidence
Infant
Infant, Newborn
Infant, Newborn, Diseases - epidemiology
Longitudinal Studies
Male
Neoplasms - epidemiology
Pregnancy
Pregnancy Outcome - epidemiology
Reproductive Techniques, Assisted - statistics & numerical data
Review
Risk Assessment
Risk Factors
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Summary:Children conceived via assisted reproductive technologies （ART） are nowadays a substantial proportion of the population. It is important to follow up these children and evaluate whether they have elevated health risks com- pared to naturally conceived （NC） children. In recent years there has been a lot of work in this field. This review will summarize what is known about the health of ART-conceived children, encompassing neonatal outcomes, birth de- fects, growth and gonadal developments, physical health, neurological and neurodevelopmental outcomes, psycho- social developments, risk for cancer, and epigenetic abnormalities. Most of the children conceived after ART are normal. However, there is increasing evidence that ART-conceived children are at higher risk of poor perinatal out- come, birth defects, and epigenetic disorders, and the mechanism（s） leading to these changes have not been eluci- dated. Continuous follow-up of children after ART is of great importance as they progress through adolescence into adulthood, and new ART techniques are constantly being introduced.
ISSN:1673-1581
1862-1783
DOI:10.1631/jzus.b1200348