Low erythrocyte catalase enzyme activity is correlated with high serum total homocysteine levels in Tunisian patients with acute myocardial infarction

An imbalance between pro-oxidants and antioxidant systems has been suggested to be implicated in the physiopathology of acute myocardial infarction (AMI). We aimed to evaluate the antioxidant capacity in Tunisian patients and to assess the possible relationship between erythrocyte catalase enzyme ac...

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Bibliographic Details
Published in:Diagnostic pathology 2013-04, Vol.8 (1), p.68-68, Article 68
Main Authors: Noichri, Yosri, Chalghoum, Abdelkader, Chkioua, Latifa, Baudin, Bruno, Ernez, Samia, Ferchichi, Salima, Miled, Abdelhédi
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Antioxidants
Antioxidants - metabolism
Apolipoproteins
Cardiac patients
Cardiovascular disease
Catalase - blood
Enzymes
Erythrocytes - enzymology
Female
Fluorescence
Heart attack
Heart attacks
Homocysteine
Homocysteine - blood
Humans
Lipid peroxidation
Lipid Peroxidation - physiology
Male
Medical research
Medicine, Experimental
Middle Aged
Myocardial Infarction - enzymology
Reactive Oxygen Species - metabolism
Rodents
Thiobarbituric Acid Reactive Substances - metabolism
Tunisia
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Summary:An imbalance between pro-oxidants and antioxidant systems has been suggested to be implicated in the physiopathology of acute myocardial infarction (AMI). We aimed to evaluate the antioxidant capacity in Tunisian patients and to assess the possible relationship between erythrocyte catalase enzyme activity and hyperhomocysteinaemia. 108 patients with AMI and 81 healthy subjects were enrolled in this study. Catalase erythrocyte enzyme activity was determined spectrophotometrically whereas "total antioxidant status" (TAS) concentration was measured by a commercially available method. Serum total homocysteine (tHcy) level was determined by a fluorescence polarization immunoassay (FPIA). Lipid peroxidation was measured with a fluorimetric method as "thiobarbituric acid reactive substances" (TBARS). Compared with healthy subjects, patients with AMI had significantly lower catalase activity (P
ISSN:1746-1596
1746-1596
DOI:10.1186/1746-1596-8-68