High expression of cancer stem cell markers in cholangiolocellular carcinoma

Purpose Cholangiolocellular carcinoma (CLC) is an extremely rare malignant liver tumor. It is thought to originate from the ductules and/or canals of Hering, where hepatic stem cells (HpSC) are located, but there are few reports on cancer stem cell markers in CLC. Thus, we evaluated the significance...

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Bibliographic Details
Published in:Surgery today (Tokyo, Japan) Japan), 2013-06, Vol.43 (6), p.654-660
Main Authors: Iwahashi, Shuichi, Utsunomiya, Tohru, Shimada, Mitsuo, Saito, Yu, Morine, Yuji, Imura, Satoru, Ikemoto, Tetsuya, Mori, Hiroki, Hanaoka, Jun, Bando, Yoshimi
Format: Article
Language:English
Subjects:
AC133 Antigen
Aged
Antigens, CD - metabolism
Antigens, Neoplasm - analysis
Biomarkers, Tumor - metabolism
Cell Adhesion Molecules - analysis
Cholangiocarcinoma - diagnosis
Cholangiocarcinoma - metabolism
Cholangiocarcinoma - pathology
Epithelial Cell Adhesion Molecule
Female
Glycoproteins - metabolism
Humans
Hyaluronan Receptors - metabolism
Immunohistochemistry
Liver Neoplasms - diagnosis
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Staging
Neoplastic Stem Cells - pathology
Original
Original Article
Peptides - metabolism
Surgery
Surgical Oncology
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Summary:Purpose Cholangiolocellular carcinoma (CLC) is an extremely rare malignant liver tumor. It is thought to originate from the ductules and/or canals of Hering, where hepatic stem cells (HpSC) are located, but there are few reports on cancer stem cell markers in CLC. Thus, we evaluated the significance of cancer stem cell markers, including CD133, CD44, and EpCAM, in CLC. Methods The subjects of this study were three patients with CLC and one patient with an intermediate type of combined hepatocellular cholangiocarcinoma (CHC). The cancer cell markers, CK7, CK19, and EMA, were evaluated immunohistochemically. Results Histological examination of the CLC revealed morphologically cholangiolar features and immunohistochemical examination revealed positivity for CD133, CD44, and EpCAM. On the other hand, in the intermediate type of CHC, only CD44 was positive, whereas CD133 and EpCAM were negative. Conclusion CLC may have stronger features derived from HpSCs than an intermediate type of CHC.
ISSN:0941-1291
1436-2813
DOI:10.1007/s00595-012-0437-9