Effect of high-fat diet on metabolic indices, cognition, and neuronal physiology in aging F344 rats

Abstract The prevalence of obesity and type 2 diabetes increases with age. Despite this, few studies have examined these conditions simultaneously in aged animals, and fewer studies have measured the impact of these conditions on brain function. Using an established animal model of brain aging (F344...

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Published in:Neurobiology of aging 2013-08, Vol.34 (8), p.1977-1987
Main Authors: Pancani, Tristano, Anderson, Katie L, Brewer, Lawrence D, Kadish, Inga, DeMoll, Chris, Landfield, Philip W, Blalock, Eric M, Porter, Nada M, Thibault, Olivier
Format: Article
Language:English
Subjects:
Adiponectin
Adiponectin - metabolism
Aging
Aging - metabolism
Aging - physiology
Aging - psychology
AHP
Animals
Calcium
Calcium - metabolism
Cognition
Diabetes Mellitus, Type 2 - etiology
Diet, High-Fat - adverse effects
Disease Progression
Hippocampus
Hippocampus - metabolism
Hippocampus - physiopathology
Internal Medicine
Learning
Male
Memory Disorders - etiology
Memory Disorders - metabolism
Memory Disorders - psychology
Metabolism
Neurology
Obesity - etiology
Rats
Rats, Inbred F344
Risk Factors
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Summary:Abstract The prevalence of obesity and type 2 diabetes increases with age. Despite this, few studies have examined these conditions simultaneously in aged animals, and fewer studies have measured the impact of these conditions on brain function. Using an established animal model of brain aging (F344 rats), we investigated whether a high-fat diet (HFD) exacerbates cognitive decline and the hippocampal calcium-dependent afterhyperpolarization (a marker of age-dependent calcium dysregulation). Young and mid-aged animals were maintained on control or HFD for 4.5 months, and peripheral metabolic variables, cognitive function, and electrophysiological responses to insulin in the hippocampus were measured. HFD increased lipid accumulation in the periphery, although overt diabetes did not develop, nor were spatial learning and memory altered. Hippocampal adiponectin levels were reduced in aging animals but were unaffected by HFD. For the first time, however, we show that the AHP is sensitive to insulin, and that this sensitivity is reduced by HFD. Interestingly, although peripheral glucose regulation was relatively insensitive to HFD, the brain appeared to show greater sensitivity to HFD in F344 rats.
ISSN:0197-4580
1558-1497
DOI:10.1016/j.neurobiolaging.2013.02.019