Self-powered microfluidic chips for multiplexed protein assays from whole blood

We report herein on a self-powered, self-contained microfluidic-based chip designed to separate plasma from whole blood, and then execute an assay of a multiplexed panel of plasma biomarker proteins. The power source is based upon a chemical reaction that is catalytically triggered by the push of a...

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Bibliographic Details
Published in:Lab on a chip 2009-01, Vol.9 (14), p.2016-2020
Main Authors: Qin, Lidong, Vermesh, Ophir, Shi, Qihui, Heath, James R
Format: Article
Language:English
Subjects:
Biomarkers - blood
Blood Chemical Analysis - instrumentation
Blood Proteins - analysis
Dimethylpolysiloxanes - chemistry
Humans
Microfluidic Analytical Techniques - instrumentation
Nylons - chemistry
Peroxides - chemistry
Pressure
Sensitivity and Specificity
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Summary:We report herein on a self-powered, self-contained microfluidic-based chip designed to separate plasma from whole blood, and then execute an assay of a multiplexed panel of plasma biomarker proteins. The power source is based upon a chemical reaction that is catalytically triggered by the push of a button on the chip. We demonstrate assays of a dozen blood-based protein biomarkers using this automated, self-contained device. This platform can potentially permit high throughput, accurate, multiplexed blood diagnostic measurements in remote locations and by minimally trained individuals.
ISSN:1473-0197
1473-0189
DOI:10.1039/b821247c