The Vitamin D Receptor (VDR) Gene Polymorphisms in Turkish Brain Cancer Patients

Objective. It has been stated that brain cancers are an increasingly serious issue in many parts of the world. The aim of our study was to determine a possible relationship between Vitamin D receptor (VDR) gene polymorphisms and the risk of glioma and meningioma. Methods. We investigated the VDR Taq...

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Bibliographic Details
Published in:BioMed research international 2013-01, Vol.2013 (2013), p.1-6
Main Authors: Yaylim, I., Zeybek, Ümit, Gökçe, Muhammed Oğuz, Yiğitbaşı, Nihal, Yurdum, Leman Melis, Turan, Saime, Cacina, Canan, Toptaş, Bahar, Kafadar, Ali Metin
Format: Article
Language:English
Subjects:
Adult
Brain cancer
Brain Neoplasms - genetics
Case-Control Studies
Cell receptors
Demography
Gene Frequency - genetics
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease
Genetic research
Genetic susceptibility
Glioma - genetics
Haplotypes - genetics
Humans
Identification and classification
Meningioma - genetics
Middle Aged
Polymorphism, Genetic
Receptors, Calcitriol - genetics
Risk Factors
Turkey
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Summary:Objective. It has been stated that brain cancers are an increasingly serious issue in many parts of the world. The aim of our study was to determine a possible relationship between Vitamin D receptor (VDR) gene polymorphisms and the risk of glioma and meningioma. Methods. We investigated the VDR Taq-I and VDR Fok-I gene polymorphisms in 100 brain cancer patients (including 44 meningioma cases and 56 glioma cases) and 122 age-matched healthy control subjects. This study was performed by polymerase chain reaction-based restriction fragment length polymorphism (RF LP). Results. VDR Fok-I ff genotype was significantly increased in meningioma patients (15.9%) compared with controls (2.5%), and carriers of Fok-I ff genotype had a 6.47-fold increased risk for meningioma cases. There was no significant difference between patients and controls for VDR Taq-I genotypes and alleles. Conclusions. We suggest that VDR Fok-I genotypes might affect the development of meningioma.
ISSN:2314-6133
2314-6141
DOI:10.1155/2013/295791