Effect of Tea (Camellia sinensis) and Olive (Olea europaea L.) Leaves Extracts on Male Mice Exposed to Diazinon

The present study was aimed to evaluate the effects of tea and olive leaves extracts and their combination in male mice intoxicated with a sublethal concentration of diazinon. Exposure of mice to 6.5 mg/kg body weight of diazinon for seven weeks resulted in statistical increases of serum alanine ami...

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Bibliographic Details
Published in:BioMed research international 2013-01, Vol.2013 (2013), p.1-6
Main Authors: al-Attar, Atef M., Abu Zeid, Isam M.
Format: Article
Language:English
Subjects:
Alanine Transaminase - blood
Alkaline Phosphatase - blood
Animals
Aspartate Aminotransferases - blood
Blood Glucose - metabolism
Camellia sinensis - chemistry
Cholesterol - blood
Creatine Kinase - blood
Creatinine - blood
Diazinon - toxicity
Environmental Exposure
gamma-Glutamyltransferase - blood
Male
Mice
Olea - chemistry
Plant Extracts - pharmacology
Plant Leaves - chemistry
Triglycerides - blood
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Summary:The present study was aimed to evaluate the effects of tea and olive leaves extracts and their combination in male mice intoxicated with a sublethal concentration of diazinon. Exposure of mice to 6.5 mg/kg body weight of diazinon for seven weeks resulted in statistical increases of serum alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transferase, alkaline phosphatase, creatine kinase, creatinine, glucose, triglycerides, and cholesterol, while the value of serum total protein was declined. Treating diazinon-intoxicated mice with tea and olive leaves extracts or their combination significantly attenuated the severe alterations in these hematobiochemical parameters. Moreover, the results indicated that the supplementation with combination of tea and olive leaves extracts led to more attenuation effect against diazinon toxicity. Additionally, these new findings suggest that the effect of tea and olive leaves extracts and their combination against toxicity of diazinon may be due to antioxidant properties of their chemical constituents. Finally, the present study indicated that the extracts of tea and olive leaves and their combination can be considered as promising therapeutic agents against hepatotoxicity, cardiotoxicity, nephrotoxicity, and metabolic disorders induced by diazinon and maybe by other toxicants and pathogenic factors.
ISSN:2314-6133
2314-6141
DOI:10.1155/2013/461415