The role of vitamin c in prevention of preterm premature rupture of membranes

Background : Preterm premature rupture of membranes (PPROM) is one of the most important complications of the pregnancy and cause perinatal morbidity and mortality. History of PPROM is a risk factor of recurrent PPROM. Vitamin C plays an important role in collagen metabolism and increases resistance...

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Bibliographic Details
Published in:Iranian red crescent medical journal 2013-02, Vol.15 (2), p.113-116
Main Authors: Ghomian, Nayereh, Takhti, Zahrah, Hafizi, Layli
Format: Article
Language:English
Subjects:
Complications
Fetal membranes
Labor, Premature
Physiological effect
Pregnancy
Rupture
Vitamin C
الأمراض
الحمل
المرأة الحامل
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Summary:Background : Preterm premature rupture of membranes (PPROM) is one of the most important complications of the pregnancy and cause perinatal morbidity and mortality. History of PPROM is a risk factor of recurrent PPROM. Vitamin C plays an important role in collagen metabolism and increases resistance maintenance of the chorioamniotic membranes. Objectives : The aim of this study is to evaluate the role of vitamin C supplementation in prevention of PPROM in women with a positive history of PPROM. Patients and Methods : This clinical trial study was performed on 170 pregnant women with the history of PPROM, with singleton pregnancy and gestational age 14 weeks in Imam-Reza Hospital, Mashhad University of Medical Sciences during 2008 to 2010. They were randomly divided into two groups. The case patients received 100 mg vitamin C daily from 14th weeks of gestation. PPROM occurrence was compared between two groups as an indicator of the protective effect of vitamin C supplements. Results : PPROM occurred in 44.7 % of controls and 31.8 % of cases (P & lt ; 0.05). PROM occurred in 34.1 % of controls and 18.8 % of cases (P & lt ; 0.05). Pregnancy was terminated at term gestation in 21.2 % of controls and 49.4 % of cases (P & lt ; 0.05). Rupture of membranes was significantly decreased in the case group. Conclusions : Vitamin C supplementations after 14th weeks of gestation can prevent from PPROM in women with the history of PPROM.
ISSN:2074-1804
2074-1812
DOI:10.5812/ircmj.5138