Characteristics of Streptococcus mutans genotypes and dental caries in children

This longitudinal cohort study evaluated the diversity, commonality, and stability of Streptococcus mutans genotypes associated with dental caries history. Sixty‐seven 5‐ and 6‐yr‐old children, considered as being at high caries risk, had plaque collected from baseline through 36 months for S. mutan...

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Bibliographic Details
Published in:European journal of oral sciences 2013-06, Vol.121 (3pt1), p.148-155
Main Authors: Cheon, Kyounga, Moser, Stephen A., Wiener, Howard W., Whiddon, Jennifer, Momeni, Stephanie S., Ruby, John D., Cutter, Gary R., Childers, Noel K.
Format: Article
Language:English
Subjects:
African Americans - genetics
Alabama - epidemiology
Chi-Square Distribution
Child
Child, Preschool
Colony Count, Microbial
dental caries
Dental Caries - epidemiology
Dental Caries - microbiology
Dental Plaque - microbiology
Dentistry
DMF Index
DNA Fingerprinting - methods
DNA, Bacterial - analysis
Follow-Up Studies
genetic diversity
Genetic Variation
Genotype
Humans
Longitudinal Studies
Oligonucleotide Array Sequence Analysis
Prevalence
Saliva - microbiology
Statistics, Nonparametric
Streptococcus mutans
Streptococcus mutans - genetics
Streptococcus mutans - isolation & purification
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Summary:This longitudinal cohort study evaluated the diversity, commonality, and stability of Streptococcus mutans genotypes associated with dental caries history. Sixty‐seven 5‐ and 6‐yr‐old children, considered as being at high caries risk, had plaque collected from baseline through 36 months for S. mutans isolation and genotyping using repetitive extragenic palindromic‐PCR (4,392 total isolates). Decayed, missing, or filled surfaces (dmfs (primary teeth)/DMFS (secondary teeth)) for each child were recorded at baseline. At baseline, 18 distinct genotypes were found among 911 S. mutans isolates from 67 children (diversity), and 13 genotypes were shared by at least two children (commonality). The number of genotypes per individual was positively associated with the proportion of decayed surfaces (p‐ds) at baseline. Twenty‐four of the 39 children who were available at follow‐up visits maintained a predominant genotype for the follow‐up periods (stability) and this was negatively associated with the p‐ds. The observed diversity, commonality, and stability of S. mutans genotypes represent a pattern of dental caries epidemiology in this high‐caries‐risk community, which suggests that fewer decayed surfaces are significantly associated with lower diversity and higher stability of S. mutans genotypes.
ISSN:0909-8836
1600-0722
DOI:10.1111/eos.12044