Cognitive Impairment Occurs in Children and Adolescents With Multiple Sclerosis: Results From a United States Network

In the largest sample studied to date, we measured cognitive functioning in children and adolescents with pediatric multiple sclerosis (n = 187) as well as those with clinically isolated syndrome (n = 44). Participants were consecutively enrolled from six United States Pediatric Multiple Sclerosis C...

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Bibliographic Details
Published in:Journal of child neurology 2013-01, Vol.28 (1), p.102-107
Main Authors: Julian, Laura, Serafin, Dana, Charvet, Leigh, Ackerson, Joseph, Benedict, Ralph, Braaten, Ellen, Brown, Tanya, O’Donnell, Ellen, Parrish, Joy, Preston, Thomas, Zaccariello, Michael, Belman, Anita, Chitnis, Tanuja, Gorman, Mark, Ness, Jayne, Patterson, Marc, Rodriguez, Moses, Waubant, Emmanuelle, Weinstock-Guttman, Bianca, Yeh, Ann, Krupp, Lauren B.
Format: Article
Language:English
Subjects:
Adolescence
Adolescent
Age
Child
Children
Cognition Disorders - diagnosis
Cognition Disorders - etiology
Cognitive ability
Cross-Sectional Studies
Female
Humans
Information processing
Logistic Models
Male
Multiple sclerosis
Multiple Sclerosis - complications
Nervous System Diseases - etiology
Neuropsychological Tests
oculomotor integration
Pediatrics
United States
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Summary:In the largest sample studied to date, we measured cognitive functioning in children and adolescents with pediatric multiple sclerosis (n = 187) as well as those with clinically isolated syndrome (n = 44). Participants were consecutively enrolled from six United States Pediatric Multiple Sclerosis Centers of Excellence. Participants had a mean of 14.8 ± 2.6 years of age and an average disease duration of 1.9 ± 2.2 years. A total of 65 (35%) children with multiple sclerosis and 8 (18%) with clinically isolated syndrome met criteria for cognitive impairment. The most frequent areas involved were fine motor coordination (54%), visuomotor integration (50%), and speeded information processing (35%). A diagnosis of multiple sclerosis (odds ratio = 3.60, confidence interval = 1.07, 12.36, P = .04) and overall neurologic disability (odds ratio = 1.47, confidence interval = 1.10, 2.10, P = .03) were the only independent predictors of cognitive impairment. Cognitive impairment may occur early in these patients, and prompt recognition is critical for their care.
ISSN:0883-0738
1708-8283
DOI:10.1177/0883073812464816