Loading…
Cognitive Impairment Occurs in Children and Adolescents With Multiple Sclerosis: Results From a United States Network
In the largest sample studied to date, we measured cognitive functioning in children and adolescents with pediatric multiple sclerosis (n = 187) as well as those with clinically isolated syndrome (n = 44). Participants were consecutively enrolled from six United States Pediatric Multiple Sclerosis C...
Saved in:
| Published in: | Journal of child neurology 2013-01, Vol.28 (1), p.102-107 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | cdi_FETCH-LOGICAL-c378t-dd342cabebe092aa34633963fc9788e354e0e54580e1b89f3d4b6f9ea3d1c2223 |
| container_end_page | 107 |
| container_issue | 1 |
| container_start_page | 102 |
| container_title | Journal of child neurology |
| container_volume | 28 |
| creator | Julian, Laura Serafin, Dana Charvet, Leigh Ackerson, Joseph Benedict, Ralph Braaten, Ellen Brown, Tanya O’Donnell, Ellen Parrish, Joy Preston, Thomas Zaccariello, Michael Belman, Anita Chitnis, Tanuja Gorman, Mark Ness, Jayne Patterson, Marc Rodriguez, Moses Waubant, Emmanuelle Weinstock-Guttman, Bianca Yeh, Ann Krupp, Lauren B. |
| description | In the largest sample studied to date, we measured cognitive functioning in children and adolescents with pediatric multiple sclerosis (n = 187) as well as those with clinically isolated syndrome (n = 44). Participants were consecutively enrolled from six United States Pediatric Multiple Sclerosis Centers of Excellence. Participants had a mean of 14.8 ± 2.6 years of age and an average disease duration of 1.9 ± 2.2 years. A total of 65 (35%) children with multiple sclerosis and 8 (18%) with clinically isolated syndrome met criteria for cognitive impairment. The most frequent areas involved were fine motor coordination (54%), visuomotor integration (50%), and speeded information processing (35%). A diagnosis of multiple sclerosis (odds ratio = 3.60, confidence interval = 1.07, 12.36, P = .04) and overall neurologic disability (odds ratio = 1.47, confidence interval = 1.10, 2.10, P = .03) were the only independent predictors of cognitive impairment. Cognitive impairment may occur early in these patients, and prompt recognition is critical for their care. |
| doi_str_mv | 10.1177/0883073812464816 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3652651</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0883073812464816</sage_id><sourcerecordid>1268652608</sourcerecordid><originalsourceid>FETCH-LOGICAL-c378t-dd342cabebe092aa34633963fc9788e354e0e54580e1b89f3d4b6f9ea3d1c2223</originalsourceid><addsrcrecordid>eNqNkc1Lw0AQxRdRbK3ePckevUT3I9lsLoIUPwqVHlQ8LpvNpN2ySepuIvjfm1AtKgie5vB-85h5D6FTSi4oTdNLIiUnKZeUxSKWVOyhMU2JjCSTfB-NBzka9BE6CmFNCJFJRg7RiHGaJIyIMVpMm2VtW_sGeFZttPUV1C1eGNP5gG2NpyvrCg811nWBr4vGQTA9EfCLbVf4oXOt3TjAj8aBb4INx-ig1C7AyeecoOfbm6fpfTRf3M2m1_PI8FS2UVHwmBmdQw4kY1rzWHCeCV6aLJUSeBIDgSROJAGay6zkRZyLMgPNC2oYY3yCrra-my6voBhu8tqpjbeV9u-q0Vb9VGq7UsvmTXGRMJHQ3uD808A3rx2EVlW2f805XUPTBUWZjAWjLE3_gQo5uBLZo2SLmj6N4KHcXUSJGipTvyvrV86-f7Jb-OqoB6ItEPQS1LrpfN0n-7fhB_KEnt4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1268652608</pqid></control><display><type>article</type><title>Cognitive Impairment Occurs in Children and Adolescents With Multiple Sclerosis: Results From a United States Network</title><source>Sage Journals Online</source><creator>Julian, Laura ; Serafin, Dana ; Charvet, Leigh ; Ackerson, Joseph ; Benedict, Ralph ; Braaten, Ellen ; Brown, Tanya ; O’Donnell, Ellen ; Parrish, Joy ; Preston, Thomas ; Zaccariello, Michael ; Belman, Anita ; Chitnis, Tanuja ; Gorman, Mark ; Ness, Jayne ; Patterson, Marc ; Rodriguez, Moses ; Waubant, Emmanuelle ; Weinstock-Guttman, Bianca ; Yeh, Ann ; Krupp, Lauren B.</creator><creatorcontrib>Julian, Laura ; Serafin, Dana ; Charvet, Leigh ; Ackerson, Joseph ; Benedict, Ralph ; Braaten, Ellen ; Brown, Tanya ; O’Donnell, Ellen ; Parrish, Joy ; Preston, Thomas ; Zaccariello, Michael ; Belman, Anita ; Chitnis, Tanuja ; Gorman, Mark ; Ness, Jayne ; Patterson, Marc ; Rodriguez, Moses ; Waubant, Emmanuelle ; Weinstock-Guttman, Bianca ; Yeh, Ann ; Krupp, Lauren B. ; Network of Pediatric MS Centers of Excellence ; for the Network of Pediatric MS Centers of Excellence</creatorcontrib><description>In the largest sample studied to date, we measured cognitive functioning in children and adolescents with pediatric multiple sclerosis (n = 187) as well as those with clinically isolated syndrome (n = 44). Participants were consecutively enrolled from six United States Pediatric Multiple Sclerosis Centers of Excellence. Participants had a mean of 14.8 ± 2.6 years of age and an average disease duration of 1.9 ± 2.2 years. A total of 65 (35%) children with multiple sclerosis and 8 (18%) with clinically isolated syndrome met criteria for cognitive impairment. The most frequent areas involved were fine motor coordination (54%), visuomotor integration (50%), and speeded information processing (35%). A diagnosis of multiple sclerosis (odds ratio = 3.60, confidence interval = 1.07, 12.36, P = .04) and overall neurologic disability (odds ratio = 1.47, confidence interval = 1.10, 2.10, P = .03) were the only independent predictors of cognitive impairment. Cognitive impairment may occur early in these patients, and prompt recognition is critical for their care.</description><identifier>ISSN: 0883-0738</identifier><identifier>EISSN: 1708-8283</identifier><identifier>DOI: 10.1177/0883073812464816</identifier><identifier>PMID: 23155206</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adolescence ; Adolescent ; Age ; Child ; Children ; Cognition Disorders - diagnosis ; Cognition Disorders - etiology ; Cognitive ability ; Cross-Sectional Studies ; Female ; Humans ; Information processing ; Logistic Models ; Male ; Multiple sclerosis ; Multiple Sclerosis - complications ; Nervous System Diseases - etiology ; Neuropsychological Tests ; oculomotor integration ; Pediatrics ; United States</subject><ispartof>Journal of child neurology, 2013-01, Vol.28 (1), p.102-107</ispartof><rights>The Author(s) 2013</rights><rights>The Author(s) 2013 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c378t-dd342cabebe092aa34633963fc9788e354e0e54580e1b89f3d4b6f9ea3d1c2223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925,79364</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23155206$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Julian, Laura</creatorcontrib><creatorcontrib>Serafin, Dana</creatorcontrib><creatorcontrib>Charvet, Leigh</creatorcontrib><creatorcontrib>Ackerson, Joseph</creatorcontrib><creatorcontrib>Benedict, Ralph</creatorcontrib><creatorcontrib>Braaten, Ellen</creatorcontrib><creatorcontrib>Brown, Tanya</creatorcontrib><creatorcontrib>O’Donnell, Ellen</creatorcontrib><creatorcontrib>Parrish, Joy</creatorcontrib><creatorcontrib>Preston, Thomas</creatorcontrib><creatorcontrib>Zaccariello, Michael</creatorcontrib><creatorcontrib>Belman, Anita</creatorcontrib><creatorcontrib>Chitnis, Tanuja</creatorcontrib><creatorcontrib>Gorman, Mark</creatorcontrib><creatorcontrib>Ness, Jayne</creatorcontrib><creatorcontrib>Patterson, Marc</creatorcontrib><creatorcontrib>Rodriguez, Moses</creatorcontrib><creatorcontrib>Waubant, Emmanuelle</creatorcontrib><creatorcontrib>Weinstock-Guttman, Bianca</creatorcontrib><creatorcontrib>Yeh, Ann</creatorcontrib><creatorcontrib>Krupp, Lauren B.</creatorcontrib><creatorcontrib>Network of Pediatric MS Centers of Excellence</creatorcontrib><creatorcontrib>for the Network of Pediatric MS Centers of Excellence</creatorcontrib><title>Cognitive Impairment Occurs in Children and Adolescents With Multiple Sclerosis: Results From a United States Network</title><title>Journal of child neurology</title><addtitle>J Child Neurol</addtitle><description>In the largest sample studied to date, we measured cognitive functioning in children and adolescents with pediatric multiple sclerosis (n = 187) as well as those with clinically isolated syndrome (n = 44). Participants were consecutively enrolled from six United States Pediatric Multiple Sclerosis Centers of Excellence. Participants had a mean of 14.8 ± 2.6 years of age and an average disease duration of 1.9 ± 2.2 years. A total of 65 (35%) children with multiple sclerosis and 8 (18%) with clinically isolated syndrome met criteria for cognitive impairment. The most frequent areas involved were fine motor coordination (54%), visuomotor integration (50%), and speeded information processing (35%). A diagnosis of multiple sclerosis (odds ratio = 3.60, confidence interval = 1.07, 12.36, P = .04) and overall neurologic disability (odds ratio = 1.47, confidence interval = 1.10, 2.10, P = .03) were the only independent predictors of cognitive impairment. Cognitive impairment may occur early in these patients, and prompt recognition is critical for their care.</description><subject>Adolescence</subject><subject>Adolescent</subject><subject>Age</subject><subject>Child</subject><subject>Children</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - etiology</subject><subject>Cognitive ability</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Information processing</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - complications</subject><subject>Nervous System Diseases - etiology</subject><subject>Neuropsychological Tests</subject><subject>oculomotor integration</subject><subject>Pediatrics</subject><subject>United States</subject><issn>0883-0738</issn><issn>1708-8283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqNkc1Lw0AQxRdRbK3ePckevUT3I9lsLoIUPwqVHlQ8LpvNpN2ySepuIvjfm1AtKgie5vB-85h5D6FTSi4oTdNLIiUnKZeUxSKWVOyhMU2JjCSTfB-NBzka9BE6CmFNCJFJRg7RiHGaJIyIMVpMm2VtW_sGeFZttPUV1C1eGNP5gG2NpyvrCg811nWBr4vGQTA9EfCLbVf4oXOt3TjAj8aBb4INx-ig1C7AyeecoOfbm6fpfTRf3M2m1_PI8FS2UVHwmBmdQw4kY1rzWHCeCV6aLJUSeBIDgSROJAGay6zkRZyLMgPNC2oYY3yCrra-my6voBhu8tqpjbeV9u-q0Vb9VGq7UsvmTXGRMJHQ3uD808A3rx2EVlW2f805XUPTBUWZjAWjLE3_gQo5uBLZo2SLmj6N4KHcXUSJGipTvyvrV86-f7Jb-OqoB6ItEPQS1LrpfN0n-7fhB_KEnt4</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Julian, Laura</creator><creator>Serafin, Dana</creator><creator>Charvet, Leigh</creator><creator>Ackerson, Joseph</creator><creator>Benedict, Ralph</creator><creator>Braaten, Ellen</creator><creator>Brown, Tanya</creator><creator>O’Donnell, Ellen</creator><creator>Parrish, Joy</creator><creator>Preston, Thomas</creator><creator>Zaccariello, Michael</creator><creator>Belman, Anita</creator><creator>Chitnis, Tanuja</creator><creator>Gorman, Mark</creator><creator>Ness, Jayne</creator><creator>Patterson, Marc</creator><creator>Rodriguez, Moses</creator><creator>Waubant, Emmanuelle</creator><creator>Weinstock-Guttman, Bianca</creator><creator>Yeh, Ann</creator><creator>Krupp, Lauren B.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130101</creationdate><title>Cognitive Impairment Occurs in Children and Adolescents With Multiple Sclerosis</title><author>Julian, Laura ; Serafin, Dana ; Charvet, Leigh ; Ackerson, Joseph ; Benedict, Ralph ; Braaten, Ellen ; Brown, Tanya ; O’Donnell, Ellen ; Parrish, Joy ; Preston, Thomas ; Zaccariello, Michael ; Belman, Anita ; Chitnis, Tanuja ; Gorman, Mark ; Ness, Jayne ; Patterson, Marc ; Rodriguez, Moses ; Waubant, Emmanuelle ; Weinstock-Guttman, Bianca ; Yeh, Ann ; Krupp, Lauren B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-dd342cabebe092aa34633963fc9788e354e0e54580e1b89f3d4b6f9ea3d1c2223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescence</topic><topic>Adolescent</topic><topic>Age</topic><topic>Child</topic><topic>Children</topic><topic>Cognition Disorders - diagnosis</topic><topic>Cognition Disorders - etiology</topic><topic>Cognitive ability</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Information processing</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - complications</topic><topic>Nervous System Diseases - etiology</topic><topic>Neuropsychological Tests</topic><topic>oculomotor integration</topic><topic>Pediatrics</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Julian, Laura</creatorcontrib><creatorcontrib>Serafin, Dana</creatorcontrib><creatorcontrib>Charvet, Leigh</creatorcontrib><creatorcontrib>Ackerson, Joseph</creatorcontrib><creatorcontrib>Benedict, Ralph</creatorcontrib><creatorcontrib>Braaten, Ellen</creatorcontrib><creatorcontrib>Brown, Tanya</creatorcontrib><creatorcontrib>O’Donnell, Ellen</creatorcontrib><creatorcontrib>Parrish, Joy</creatorcontrib><creatorcontrib>Preston, Thomas</creatorcontrib><creatorcontrib>Zaccariello, Michael</creatorcontrib><creatorcontrib>Belman, Anita</creatorcontrib><creatorcontrib>Chitnis, Tanuja</creatorcontrib><creatorcontrib>Gorman, Mark</creatorcontrib><creatorcontrib>Ness, Jayne</creatorcontrib><creatorcontrib>Patterson, Marc</creatorcontrib><creatorcontrib>Rodriguez, Moses</creatorcontrib><creatorcontrib>Waubant, Emmanuelle</creatorcontrib><creatorcontrib>Weinstock-Guttman, Bianca</creatorcontrib><creatorcontrib>Yeh, Ann</creatorcontrib><creatorcontrib>Krupp, Lauren B.</creatorcontrib><creatorcontrib>Network of Pediatric MS Centers of Excellence</creatorcontrib><creatorcontrib>for the Network of Pediatric MS Centers of Excellence</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of child neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Julian, Laura</au><au>Serafin, Dana</au><au>Charvet, Leigh</au><au>Ackerson, Joseph</au><au>Benedict, Ralph</au><au>Braaten, Ellen</au><au>Brown, Tanya</au><au>O’Donnell, Ellen</au><au>Parrish, Joy</au><au>Preston, Thomas</au><au>Zaccariello, Michael</au><au>Belman, Anita</au><au>Chitnis, Tanuja</au><au>Gorman, Mark</au><au>Ness, Jayne</au><au>Patterson, Marc</au><au>Rodriguez, Moses</au><au>Waubant, Emmanuelle</au><au>Weinstock-Guttman, Bianca</au><au>Yeh, Ann</au><au>Krupp, Lauren B.</au><aucorp>Network of Pediatric MS Centers of Excellence</aucorp><aucorp>for the Network of Pediatric MS Centers of Excellence</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cognitive Impairment Occurs in Children and Adolescents With Multiple Sclerosis: Results From a United States Network</atitle><jtitle>Journal of child neurology</jtitle><addtitle>J Child Neurol</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>28</volume><issue>1</issue><spage>102</spage><epage>107</epage><pages>102-107</pages><issn>0883-0738</issn><eissn>1708-8283</eissn><abstract>In the largest sample studied to date, we measured cognitive functioning in children and adolescents with pediatric multiple sclerosis (n = 187) as well as those with clinically isolated syndrome (n = 44). Participants were consecutively enrolled from six United States Pediatric Multiple Sclerosis Centers of Excellence. Participants had a mean of 14.8 ± 2.6 years of age and an average disease duration of 1.9 ± 2.2 years. A total of 65 (35%) children with multiple sclerosis and 8 (18%) with clinically isolated syndrome met criteria for cognitive impairment. The most frequent areas involved were fine motor coordination (54%), visuomotor integration (50%), and speeded information processing (35%). A diagnosis of multiple sclerosis (odds ratio = 3.60, confidence interval = 1.07, 12.36, P = .04) and overall neurologic disability (odds ratio = 1.47, confidence interval = 1.10, 2.10, P = .03) were the only independent predictors of cognitive impairment. Cognitive impairment may occur early in these patients, and prompt recognition is critical for their care.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>23155206</pmid><doi>10.1177/0883073812464816</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0883-0738 |
| ispartof | Journal of child neurology, 2013-01, Vol.28 (1), p.102-107 |
| issn | 0883-0738 1708-8283 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3652651 |
| source | Sage Journals Online |
| subjects | Adolescence Adolescent Age Child Children Cognition Disorders - diagnosis Cognition Disorders - etiology Cognitive ability Cross-Sectional Studies Female Humans Information processing Logistic Models Male Multiple sclerosis Multiple Sclerosis - complications Nervous System Diseases - etiology Neuropsychological Tests oculomotor integration Pediatrics United States |
| title | Cognitive Impairment Occurs in Children and Adolescents With Multiple Sclerosis: Results From a United States Network |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T21%3A21%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cognitive%20Impairment%20Occurs%20in%20Children%20and%20Adolescents%20With%20Multiple%20Sclerosis:%20Results%20From%20a%20United%20States%20Network&rft.jtitle=Journal%20of%20child%20neurology&rft.au=Julian,%20Laura&rft.aucorp=Network%20of%20Pediatric%20MS%20Centers%20of%20Excellence&rft.date=2013-01-01&rft.volume=28&rft.issue=1&rft.spage=102&rft.epage=107&rft.pages=102-107&rft.issn=0883-0738&rft.eissn=1708-8283&rft_id=info:doi/10.1177/0883073812464816&rft_dat=%3Cproquest_pubme%3E1268652608%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c378t-dd342cabebe092aa34633963fc9788e354e0e54580e1b89f3d4b6f9ea3d1c2223%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1268652608&rft_id=info:pmid/23155206&rft_sage_id=10.1177_0883073812464816&rfr_iscdi=true |