5-HT2A receptor antagonist M100907 reduces serotonin synthesis: An autoradiographic study

Highlights ► The terminal 5-HT2A receptors are involved in the regulation of 5-HT synthesis. ► A single dose of M100907 caused a significant decrease in the brain 5-HT synthesis. ► The M100907 treatment produces a large reduction of the 5-HT synthesis in the limbic structure.

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Bibliographic Details
Published in:Brain research bulletin 2012-01, Vol.87 (1), p.44-49
Main Authors: Hasegawa, Shu, Fikre-Merid, Maraki, Diksic, Mirko
Format: Article
Language:English
Subjects:
5-HT2A receptor antagonist
Animals
Autoradiography
Autoradiography - methods
Brain - anatomy & histology
Brain - drug effects
Brain - metabolism
Fluorobenzenes - pharmacology
M100907
Male
Neurology
Piperidines - pharmacology
Rats
Rats, Sprague-Dawley
Receptor, Serotonin, 5-HT2A - metabolism
Serotonin - biosynthesis
Serotonin 5-HT2 Receptor Antagonists - pharmacology
Serotonin synthesis rate
α-[14C]methyl-l-tryptophan
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Description
Summary:Highlights ► The terminal 5-HT2A receptors are involved in the regulation of 5-HT synthesis. ► A single dose of M100907 caused a significant decrease in the brain 5-HT synthesis. ► The M100907 treatment produces a large reduction of the 5-HT synthesis in the limbic structure.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2011.10.009