Tight Junction Proteins and Oxidative Stress in Heavy Metals-Induced Nephrotoxicity

Kidney is a target organ for heavy metals. They accumulate in several segments of the nephron and cause profound alterations in morphology and function. Acute intoxication frequently causes acute renal failure. The effects of chronic exposure have not been fully disclosed. In recent years increasing...

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Bibliographic Details
Published in:BioMed research international 2013-01, Vol.2013 (2013), p.1-14
Main Authors: Debray-García, Yazmin, Bautista-García, Pablo, Rodríguez-Muñoz, Rafael, Molina-Jijón, Eduardo, Reyes, José L., Namorado, María del Carmen
Format: Article
Language:English
Subjects:
Acute intoxication
Acute Kidney Injury - chemically induced
Acute Kidney Injury - pathology
Antioxidants - metabolism
Biomedical research
Glucose
Heavy metals
Humans
Kidney - drug effects
Kidney - physiopathology
Kidney Glomerulus - drug effects
Kidney Glomerulus - pathology
Kidney Tubules, Proximal - drug effects
Kidney Tubules, Proximal - pathology
Metals
Metals, Heavy - toxicity
Nephrons - drug effects
Nephrons - pathology
Oxidative Stress
Permeability
Proteins
Review
Rodents
Tight Junction Proteins - metabolism
Tretinoin - administration & dosage
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Summary:Kidney is a target organ for heavy metals. They accumulate in several segments of the nephron and cause profound alterations in morphology and function. Acute intoxication frequently causes acute renal failure. The effects of chronic exposure have not been fully disclosed. In recent years increasing awareness of the consequences of their presence in the kidney has evolved. In this review we focus on the alterations induced by heavy metals on the intercellular junctions of the kidney. We describe that in addition to the proximal tubule, which has been recognized as the main site of accumulation and injury, other segments of the nephron, such as glomeruli, vessels, and distal nephron, show also deleterious effects. We also emphasize the participation of oxidative stress as a relevant component of the renal damage induced by heavy metals and the beneficial effect that some antioxidant drugs, such as vitamin A (all-trans-retinoic acid) and vitamin E (α-tocopherol), depict on the morphological and functional alterations induced by heavy metals.
ISSN:2314-6133
2314-6141
DOI:10.1155/2013/730789