Anti-inflammatory and anti-oxidative effects of corilagin in a rat model of acute cholestasis

Nowadays, treatments for cholestasis remain largely nonspecific and often ineffective. Recent studies showed that inflammatory injuries and oxidative stress occur in the liver with cholestasis. In this study, we would use corilagin to treat the animal model of acute cholestasis in order to define th...

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Bibliographic Details
Published in:BMC gastroenterology 2013-05, Vol.13 (1), p.79-79, Article 79
Main Authors: Jin, Feng, Cheng, Du, Tao, Jun-Yan, Zhang, Shu-Ling, Pang, Ran, Guo, Yuan-Jin, Ye, Pian, Dong, Ji-Hua, Zhao, Lei
Format: Article
Language:English
Subjects:
Acute Disease
Alanine Transaminase - blood
Analysis
Analysis of Variance
Animals
Anti-Inflammatory Agents - therapeutic use
Aspartate Aminotransferases - blood
Bile
Bilirubin - blood
Cholagogues and Choleretics - therapeutic use
Cholestasis
Cholestasis - blood
Cholestasis - drug therapy
Cholestasis - pathology
Colleges & universities
Dexamethasone - pharmacology
Dexamethasone - therapeutic use
Disease Models, Animal
Drug therapy
Gastroenterology
Glucosides - pharmacology
Glucosides - therapeutic use
Hydrolyzable Tannins
Jaundice, Obstructive
Liver
Liver - metabolism
Male
Malondialdehyde - metabolism
Medical research
NF-kappa B - biosynthesis
Nitric Oxide - metabolism
Oxidative Stress - drug effects
Peroxidase - metabolism
Physiological aspects
Rats
Rats, Sprague-Dawley
Rodents
Science
Superoxide Dismutase - metabolism
Tannins
Ursodeoxycholic Acid - pharmacology
Ursodeoxycholic Acid - therapeutic use
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Summary:Nowadays, treatments for cholestasis remain largely nonspecific and often ineffective. Recent studies showed that inflammatory injuries and oxidative stress occur in the liver with cholestasis. In this study, we would use corilagin to treat the animal model of acute cholestasis in order to define the activity to interfere with inflammation-related and oxidative stress pathway in cholestatic pathogenesis. Rats were administrated with alpha-naphthylisothiocyanate to establish model of cholestasis and divided into corilagin, ursodeoxycholic acid, dexamethasone, model and normal groups with treatment of related agent. At 24h, 48h and 72h time points after administration, living condition, serum markers of liver damage, pathological changes of hepatic tissue, nuclear factor (NF)-kappaB, myeloperoxidase (MPO), malondialdehyde (MDA), superoxide dismutase (SOD) and nitric oxide (NO) were examined and observed. Compared to model group, corilagin had remarkable effect on living condition, pathological manifestation of liver tissue, total bilirubin, direct bilirubin, (P
ISSN:1471-230X
1471-230X
DOI:10.1186/1471-230X-13-79