PKR-dependent inflammatory signals

Double-stranded RNA-dependent protein kinase (PKR) is implicated in inflammation and immune dysfunction through its regulation of mitogen-activated protein kinases, interferon regulatory factor 3, nuclear factor κB, apoptosis, and autophagy pathways. A study shows that PKR is also required for the a...

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Bibliographic Details
Published in:Science signaling 2012-10, Vol.5 (247), p.pe47-pe47
Main Authors: Kang, Rui, Tang, Daolin
Format: Article
Language:English
Subjects:
Animals
eIF-2 Kinase - immunology
Extracellular Signal-Regulated MAP Kinases - immunology
HMGB1 Protein - immunology
Humans
Inflammasomes - immunology
Inflammation - immunology
Interferon Regulatory Factor-3 - immunology
Signal Transduction - immunology
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Summary:Double-stranded RNA-dependent protein kinase (PKR) is implicated in inflammation and immune dysfunction through its regulation of mitogen-activated protein kinases, interferon regulatory factor 3, nuclear factor κB, apoptosis, and autophagy pathways. A study shows that PKR is also required for the activation of inflammasomes and the subsequent release of high-mobility group box 1 (HMGB1) protein, a proinflammatory cytokine. Thus, the cell stress kinase PKR has multifaceted roles in the regulation of inflammatory immune responses, and PKR and HMGB1 are attractive targets for inflammasome-associated diseases.
ISSN:1945-0877
1937-9145
DOI:10.1126/scisignal.2003511