A case of oligoasthenoteratozoospermia with AZFc deletion and persistent oxidative stress

Y-chromosomal microdeletions are associated with severe oligozoospermia or azoospermia. AZFc microdeletions have been always associated with severe oligozoospermia or azoospermia with a rare occurrence in individuals with other infertility phenotypes. We report here a rare case of an infertile man c...

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Bibliographic Details
Published in:Indian journal of human genetics 2012-09, Vol.18 (3), p.359-362
Main Authors: Singh, Rajender, Kaleem, Ahmad, Narayana, Sankhwar, Mahdi, Abbas
Format: Article
Language:English
Subjects:
Case Report
Case studies
Causes of
Complications and side effects
Diagnosis
Gene mutations
Genes
Genetic aspects
Infertility
Infertility, Male
Males
Oxidative stress
Sex chromosome abnormalities
Sperm
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Summary:Y-chromosomal microdeletions are associated with severe oligozoospermia or azoospermia. AZFc microdeletions have been always associated with severe oligozoospermia or azoospermia with a rare occurrence in individuals with other infertility phenotypes. We report here a rare case of an infertile man carrying AZFc deletion, whose semen picture is oligoasthenoteratozoospermia complexed with seminal oxidative stress. Anti-oxidant therapy could make no change in either oxidative stress biomarker levels of semen, seminal parameters or serum hormone levels. Therefore, oligoasthenoteratozoospermia in the present case correlates with AZFc deletion, and high content of abnormal sperm eventually might be responsible for persistently elevated reactive oxygen species levels. Understanding the function of genes in AZFc region could help decipher the exact cause of the phenotype in such cases.
ISSN:0971-6866
1998-362X
DOI:10.4103/0971-6866.108037