A novel 11;18 translocation in a case of acute myeloid leukemia with maturation

Acute myeloid leukemia with maturation (AML-M2) is associated with the 8;21 translocation. For the first time in an adult patient with AML-M2, a novel unbalanced translocation involving the short arm of chromosome 11 and long arm of chromosome18 with new breakpoints is presented. CD82 on band 11p11....

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Bibliographic Details
Published in:Indian journal of human genetics 2012-09, Vol.18 (3), p.369-372
Main Authors: Devi, G, Ahmed, Faiq, Khadke, Kavita, Murthy, Sudha, Rajappa, Senthil
Format: Article
Language:English
Subjects:
Apoptosis
Bone marrow
Case Report
Case studies
Causes of
Cell cycle
Chromosomes
Diagnosis
Health aspects
Kinases
Leukemia
Mutation
Pathogenesis
Translocation (Genetics)
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Summary:Acute myeloid leukemia with maturation (AML-M2) is associated with the 8;21 translocation. For the first time in an adult patient with AML-M2, a novel unbalanced translocation involving the short arm of chromosome 11 and long arm of chromosome18 with new breakpoints is presented. CD82 on band 11p11.2 and GATA 6 on 18q11.2 may play a role in the pathogenesis of de novo AML M2. The report with translocation (11;18)(p11.2;q11.2), as the sole cytogenetic abnormality provides more data on the leukemogenesis of de novo AML M2.
ISSN:0971-6866
1998-362X
DOI:10.4103/0971-6866.108050