A preclinical evaluation of Minnelide as a therapeutic agent against pancreatic cancer

Pancreatic cancer is one of the most lethal human malignancies with an all-stage 5-year survival frequency of

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Bibliographic Details
Published in:Science translational medicine 2012-10, Vol.4 (156), p.156ra139-156ra139
Main Authors: Chugh, Rohit, Sangwan, Veena, Patil, Satish P, Dudeja, Vikas, Dawra, Rajinder K, Banerjee, Sulagna, Schumacher, Robert J, Blazar, Bruce R, Georg, Gunda I, Vickers, Selwyn M, Saluja, Ashok K
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents, Alkylating - pharmacology
Cell Line, Tumor
Cell Survival
Diterpenes - pharmacology
Drug Screening Assays, Antitumor
Epoxy Compounds - pharmacology
Female
Humans
Mice
Mice, Nude
Mice, SCID
Neoplasm Transplantation
Organophosphates - pharmacology
Pancreatic Neoplasms - drug therapy
Phenanthrenes - pharmacology
Phosphoric Monoester Hydrolases - metabolism
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Description
Summary:Pancreatic cancer is one of the most lethal human malignancies with an all-stage 5-year survival frequency of
ISSN:1946-6234
1946-6242
DOI:10.1126/scitranslmed.3004334