Predictors of Serum Total IgE in a Random Sample of 7–17 Year Old Children

Background. There is little knowledge of the causes for raised serum total immunoglobulin E (IgE) in children. We investigated the association between perinatal, socioeconomic, demographic, clinical, paraclinical, and early life factors, and total serum IgE. Methods. In a random sample of 7–17 year...

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Published in:ISRN allergy 2011, Vol.2011 (2011), p.1-4
Main Authors: Backer, Vibeke, Thomsen, Simon Francis, Fenger, Mogens, Strømgaard, Sofie
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Language:English
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Allergies
Asthma
Clinical Study
Dermatitis
Hay fever
Interviews
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description Background. There is little knowledge of the causes for raised serum total immunoglobulin E (IgE) in children. We investigated the association between perinatal, socioeconomic, demographic, clinical, paraclinical, and early life factors, and total serum IgE. Methods. In a random sample of 7–17 year old children, data on possible risk factors were collected using a questionnaire and total serum IgE was measured in venous blood. Airway responsiveness to inhaled histamine was measured and skin prick tests were performed using common aeroallergens. Data was analysed using linear regression. Results. Positive skin prick test (P
doi_str_mv 10.5402/2011/169859
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S. ; Fukushima, A.</contributor><creatorcontrib>Backer, Vibeke ; Thomsen, Simon Francis ; Fenger, Mogens ; Strømgaard, Sofie ; Zacharasiewicz, A. S. ; Fukushima, A.</creatorcontrib><description>Background. There is little knowledge of the causes for raised serum total immunoglobulin E (IgE) in children. We investigated the association between perinatal, socioeconomic, demographic, clinical, paraclinical, and early life factors, and total serum IgE. Methods. In a random sample of 7–17 year old children, data on possible risk factors were collected using a questionnaire and total serum IgE was measured in venous blood. Airway responsiveness to inhaled histamine was measured and skin prick tests were performed using common aeroallergens. Data was analysed using linear regression. Results. Positive skin prick test (P&lt;.001), airway hyperresponsiveness (P=.003), atopic dermatitis (P=.046), and parental predisposition to allergy (P=.047) showed a significant relation to serum total IgE levels. There was no association of smoking to serum total IgE. Conclusions. This study showed a strong positive relationship between markers of the atopic syndrome and serum total IgE levels in children. In contrast to some earlier studies, we did not find a significant relation between smoking status and IgE.</description><identifier>ISSN: 2090-5521</identifier><identifier>EISSN: 2090-553X</identifier><identifier>DOI: 10.5402/2011/169859</identifier><identifier>PMID: 23724221</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Allergies ; Asthma ; Clinical Study ; Dermatitis ; Hay fever ; Interviews</subject><ispartof>ISRN allergy, 2011, Vol.2011 (2011), p.1-4</ispartof><rights>Copyright © 2011 Sofie Strømgaard et al.</rights><rights>Copyright © 2011 Sofie Strømgaard et al. Sofie Strømgaard et al. 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Positive skin prick test (P&lt;.001), airway hyperresponsiveness (P=.003), atopic dermatitis (P=.046), and parental predisposition to allergy (P=.047) showed a significant relation to serum total IgE levels. There was no association of smoking to serum total IgE. Conclusions. This study showed a strong positive relationship between markers of the atopic syndrome and serum total IgE levels in children. 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subjects Allergies
Asthma
Clinical Study
Dermatitis
Hay fever
Interviews
title Predictors of Serum Total IgE in a Random Sample of 7–17 Year Old Children
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