Neural mechanisms underlying auditory feedback control of speech

The neural substrates underlying auditory feedback control of speech were investigated using a combination of functional magnetic resonance imaging (fMRI) and computational modeling. Neural responses were measured while subjects spoke monosyllabic words under two conditions: (i) normal auditory feed...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2008-02, Vol.39 (3), p.1429-1443
Main Authors: Tourville, Jason A., Reilly, Kevin J., Guenther, Frank H.
Format: Article
Language:English
Subjects:
Adult
Algorithms
Auditory feedback control
Auditory Perception - physiology
Brain
Brain Mapping
Cerebral Cortex - anatomy & histology
Cerebral Cortex - physiology
Data Interpretation, Statistical
Effective connectivity
Feedback - physiology
Female
Functional magnetic resonance imaging
Humans
Hypotheses
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Models, Neurological
Models, Statistical
Neural modeling
Oxygen - blood
Quality of life
Speech - physiology
Speech production
Structural equation modeling
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Summary:The neural substrates underlying auditory feedback control of speech were investigated using a combination of functional magnetic resonance imaging (fMRI) and computational modeling. Neural responses were measured while subjects spoke monosyllabic words under two conditions: (i) normal auditory feedback of their speech and (ii) auditory feedback in which the first formant frequency of their speech was unexpectedly shifted in real time. Acoustic measurements showed compensation to the shift within approximately 136 ms of onset. Neuroimaging revealed increased activity in bilateral superior temporal cortex during shifted feedback, indicative of neurons coding mismatches between expected and actual auditory signals, as well as right prefrontal and Rolandic cortical activity. Structural equation modeling revealed increased influence of bilateral auditory cortical areas on right frontal areas during shifted speech, indicating that projections from auditory error cells in posterior superior temporal cortex to motor correction cells in right frontal cortex mediate auditory feedback control of speech.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2007.09.054