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Embryonic Stem Cell‐Based Cardiopatches Improve Cardiac Function in Infarcted Rats
Pluripotent stem cell‐seeded cardiopatches hold promise for in situ regeneration of infarcted hearts. Here, we describe a novel cardiopatch based on bone morphogenetic protein 2‐primed cardiac‐committed mouse embryonic stem cells, embedded into biodegradable fibrin matrices and engrafted onto infarc...
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| Published in: | Stem cells translational medicine 2012-03, Vol.1 (3), p.248-260 |
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| creator | Vallée, Jean-Paul Hauwel, Mathieu Lepetit-Coiffé, Matthieu Bei, Wang Montet-Abou, Karin Meda, Paolo Gardier, Stephany Zammaretti, Prisca Kraehenbuehl, Thomas P. Herrmann, Francois Hubbell, Jeffrey A. Jaconi, Marisa E. |
| description | Pluripotent stem cell‐seeded cardiopatches hold promise for in situ regeneration of infarcted hearts. Here, we describe a novel cardiopatch based on bone morphogenetic protein 2‐primed cardiac‐committed mouse embryonic stem cells, embedded into biodegradable fibrin matrices and engrafted onto infarcted rat hearts. For in vivo tracking of the engrafted cardiac‐committed cells, superparamagnetic iron oxide nanoparticles were magnetofected into the cells, thus enabling detection and functional evaluation by high‐resolution magnetic resonance imaging. Six weeks after transplantation into infarcted rat hearts, both local (p < .04) and global (p < .015) heart function, as well as the left ventricular dilation (p < .0011), were significantly improved (p < .001) as compared with hearts receiving cardiopatches loaded with iron nanoparticles alone. Histological analysis revealed that the fibrin scaffolds had degraded over time and clusters of myocyte enhancer factor 2‐positive cardiac‐committed cells had colonized most of the infarcted myocardium, including the fibrotic area. De novo CD31‐positive blood vessels were formed in the vicinity of the transplanted cardiopatch. Altogether, our data provide evidence that stem cell‐based cardiopatches represent a promising therapeutic strategy to achieve efficient cell implantation and improved global and regional cardiac function after myocardial infarction. |
| doi_str_mv | 10.5966/sctm.2011-0028 |
| format | article |
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Here, we describe a novel cardiopatch based on bone morphogenetic protein 2‐primed cardiac‐committed mouse embryonic stem cells, embedded into biodegradable fibrin matrices and engrafted onto infarcted rat hearts. For in vivo tracking of the engrafted cardiac‐committed cells, superparamagnetic iron oxide nanoparticles were magnetofected into the cells, thus enabling detection and functional evaluation by high‐resolution magnetic resonance imaging. Six weeks after transplantation into infarcted rat hearts, both local (p < .04) and global (p < .015) heart function, as well as the left ventricular dilation (p < .0011), were significantly improved (p < .001) as compared with hearts receiving cardiopatches loaded with iron nanoparticles alone. Histological analysis revealed that the fibrin scaffolds had degraded over time and clusters of myocyte enhancer factor 2‐positive cardiac‐committed cells had colonized most of the infarcted myocardium, including the fibrotic area. De novo CD31‐positive blood vessels were formed in the vicinity of the transplanted cardiopatch. Altogether, our data provide evidence that stem cell‐based cardiopatches represent a promising therapeutic strategy to achieve efficient cell implantation and improved global and regional cardiac function after myocardial infarction.</description><identifier>ISSN: 2157-6564</identifier><identifier>EISSN: 2157-6580</identifier><identifier>DOI: 10.5966/sctm.2011-0028</identifier><identifier>PMID: 23197784</identifier><language>eng</language><publisher>United States: AlphaMed Press</publisher><subject>Animals ; Biodegradability ; Blood vessels ; Bone morphogenetic protein 2 ; Cardiac ; Cardiac function ; Cell Differentiation ; Clinical trials ; Data analysis ; Embryo cells ; Embryonic stem cells ; Embryonic Stem Cells - cytology ; Embryonic Stem Cells - physiology ; Fibrin ; Genetic engineering ; Heart - physiology ; Heart attacks ; Immunoenzyme Techniques ; Iron oxides ; Magnetic Resonance Imaging ; Male ; Mice ; Myocardial infarction ; Myocardial Infarction - therapy ; Myocardium ; Myocyte enhancer factor 2 ; Nanoparticles ; NMR ; Nuclear magnetic resonance ; Original and Reviews ; Pluripotency ; Polyethylene glycol ; Rats ; Regeneration ; Stem Cell Transplantation ; Stem cells ; Studies ; Tissue engineering ; Tissue regeneration ; Ventricle ; Writing</subject><ispartof>Stem cells translational medicine, 2012-03, Vol.1 (3), p.248-260</ispartof><rights>2012 AlphaMed Press</rights><rights>2012. 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Here, we describe a novel cardiopatch based on bone morphogenetic protein 2‐primed cardiac‐committed mouse embryonic stem cells, embedded into biodegradable fibrin matrices and engrafted onto infarcted rat hearts. For in vivo tracking of the engrafted cardiac‐committed cells, superparamagnetic iron oxide nanoparticles were magnetofected into the cells, thus enabling detection and functional evaluation by high‐resolution magnetic resonance imaging. Six weeks after transplantation into infarcted rat hearts, both local (p < .04) and global (p < .015) heart function, as well as the left ventricular dilation (p < .0011), were significantly improved (p < .001) as compared with hearts receiving cardiopatches loaded with iron nanoparticles alone. Histological analysis revealed that the fibrin scaffolds had degraded over time and clusters of myocyte enhancer factor 2‐positive cardiac‐committed cells had colonized most of the infarcted myocardium, including the fibrotic area. De novo CD31‐positive blood vessels were formed in the vicinity of the transplanted cardiopatch. Altogether, our data provide evidence that stem cell‐based cardiopatches represent a promising therapeutic strategy to achieve efficient cell implantation and improved global and regional cardiac function after myocardial infarction.</description><subject>Animals</subject><subject>Biodegradability</subject><subject>Blood vessels</subject><subject>Bone morphogenetic protein 2</subject><subject>Cardiac</subject><subject>Cardiac function</subject><subject>Cell Differentiation</subject><subject>Clinical trials</subject><subject>Data analysis</subject><subject>Embryo cells</subject><subject>Embryonic stem cells</subject><subject>Embryonic Stem Cells - cytology</subject><subject>Embryonic Stem Cells - physiology</subject><subject>Fibrin</subject><subject>Genetic engineering</subject><subject>Heart - physiology</subject><subject>Heart attacks</subject><subject>Immunoenzyme Techniques</subject><subject>Iron oxides</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Mice</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Stem cells translational medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Vallée, Jean-Paul</au><au>Hauwel, Mathieu</au><au>Lepetit-Coiffé, Matthieu</au><au>Bei, Wang</au><au>Montet-Abou, Karin</au><au>Meda, Paolo</au><au>Gardier, Stephany</au><au>Zammaretti, Prisca</au><au>Kraehenbuehl, Thomas P.</au><au>Herrmann, Francois</au><au>Hubbell, Jeffrey A.</au><au>Jaconi, Marisa E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Embryonic Stem Cell‐Based Cardiopatches Improve Cardiac Function in Infarcted Rats</atitle><jtitle>Stem cells translational medicine</jtitle><addtitle>Stem Cells Transl Med</addtitle><date>2012-03</date><risdate>2012</risdate><volume>1</volume><issue>3</issue><spage>248</spage><epage>260</epage><pages>248-260</pages><issn>2157-6564</issn><eissn>2157-6580</eissn><abstract>Pluripotent stem cell‐seeded cardiopatches hold promise for in situ regeneration of infarcted hearts. Here, we describe a novel cardiopatch based on bone morphogenetic protein 2‐primed cardiac‐committed mouse embryonic stem cells, embedded into biodegradable fibrin matrices and engrafted onto infarcted rat hearts. For in vivo tracking of the engrafted cardiac‐committed cells, superparamagnetic iron oxide nanoparticles were magnetofected into the cells, thus enabling detection and functional evaluation by high‐resolution magnetic resonance imaging. Six weeks after transplantation into infarcted rat hearts, both local (p < .04) and global (p < .015) heart function, as well as the left ventricular dilation (p < .0011), were significantly improved (p < .001) as compared with hearts receiving cardiopatches loaded with iron nanoparticles alone. Histological analysis revealed that the fibrin scaffolds had degraded over time and clusters of myocyte enhancer factor 2‐positive cardiac‐committed cells had colonized most of the infarcted myocardium, including the fibrotic area. De novo CD31‐positive blood vessels were formed in the vicinity of the transplanted cardiopatch. Altogether, our data provide evidence that stem cell‐based cardiopatches represent a promising therapeutic strategy to achieve efficient cell implantation and improved global and regional cardiac function after myocardial infarction.</abstract><cop>United States</cop><pub>AlphaMed Press</pub><pmid>23197784</pmid><doi>10.5966/sctm.2011-0028</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biodegradability Blood vessels Bone morphogenetic protein 2 Cardiac Cardiac function Cell Differentiation Clinical trials Data analysis Embryo cells Embryonic stem cells Embryonic Stem Cells - cytology Embryonic Stem Cells - physiology Fibrin Genetic engineering Heart - physiology Heart attacks Immunoenzyme Techniques Iron oxides Magnetic Resonance Imaging Male Mice Myocardial infarction Myocardial Infarction - therapy Myocardium Myocyte enhancer factor 2 Nanoparticles NMR Nuclear magnetic resonance Original and Reviews Pluripotency Polyethylene glycol Rats Regeneration Stem Cell Transplantation Stem cells Studies Tissue engineering Tissue regeneration Ventricle Writing |
| title | Embryonic Stem Cell‐Based Cardiopatches Improve Cardiac Function in Infarcted Rats |
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