Isoniazid- and rifampicin-induced thrombocytopenia

Treatment of tuberculosis has many side effects. Thrombocytopenia is a serious side effect of such treatment and occurs mostly due to rifampicin (RIF). There are very few reported cases of thrombocytopenia due to isoniazid (INH). An 18-year-old female patient was diagnosed with smear-positive pulmon...

Full description

Saved in:
Bibliographic Details
Published in:Multidisciplinary respiratory medicine 2013-02, Vol.8 (1), p.13-13, Article 13
Main Authors: Yakar, Fatih, Yildiz, Namşan, Yakar, Aysun, Kılıçaslan, Zeki
Format: Article
Language:English
Subjects:
Care and treatment
Case Report
Health aspects
Isoniazid
Rifampin
Thrombocytopenia
Tuberculosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Treatment of tuberculosis has many side effects. Thrombocytopenia is a serious side effect of such treatment and occurs mostly due to rifampicin (RIF). There are very few reported cases of thrombocytopenia due to isoniazid (INH). An 18-year-old female patient was diagnosed with smear-positive pulmonary tuberculosis. A four-drug regimen [INH, RIF, ethambutol (EMB), and pyrazinamide (PZA)] was given. After the development of thrombocytopenia, the drug treatment was stopped, and a thrombocyte suspension was given until a normal thrombocyte count was obtained. After several start-stop trials, first INH and then RIF were identified as the possible causes of thrombocytopenia and were removed from the regimen. The patient was treated with EMB, streptomycin, PZA, and moxifloxacin with no further development of thrombocytopenia. The current case shows that antituberculosis drugs other than RIF and PZA may be responsible for the development of thrombocytopenia.
ISSN:1828-695X
2049-6958
2049-6958
DOI:10.1186/2049-6958-8-13