The role of MAC1 in diesel exhaust particle‐induced microglial activation and loss of dopaminergic neuron function

Increasing reports support that air pollution causes neuroinflammation and is linked to central nervous system (CNS) disease/damage. Diesel exhaust particles (DEP) are a major component of urban air pollution, which has been linked to microglial activation and Parkinson's disease‐like pathology...

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Bibliographic Details
Published in:Journal of neurochemistry 2013-06, Vol.125 (5), p.756-765
Main Authors: Levesque, Shannon, Taetzsch, Thomas, Lull, Melinda E., Johnson, Jo Anne, McGraw, Constance, Block, Michelle L.
Format: Article
Language:English
Subjects:
air pollution
Animals
brain
Cell Line
Cells, Cultured
Dopamine
Dopaminergic Neurons - drug effects
Dopaminergic Neurons - physiology
Female
inflammation‐mediated neurodegeneration
Macrophage-1 Antigen - physiology
Male
Mice
Mice, 129 Strain
Mice, Inbred C57BL
Mice, Transgenic
Microglia
Neural Inhibition - drug effects
Neural Inhibition - physiology
neuroinflammation
Neurons
oxidative stress
Particulate Matter - toxicity
Pregnancy
Rats
Rats, Inbred F344
Vehicle Emissions - toxicity
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Summary:Increasing reports support that air pollution causes neuroinflammation and is linked to central nervous system (CNS) disease/damage. Diesel exhaust particles (DEP) are a major component of urban air pollution, which has been linked to microglial activation and Parkinson's disease‐like pathology. To begin to address how DEP may exert CNS effects, microglia and neuron‐glia cultures were treated with either nanometer‐sized DEP (
ISSN:0022-3042
1471-4159
DOI:10.1111/jnc.12231