Compartmentalizing the embryo: Lipids and septate junction mediated barrier function

Lipid phosphate phosphatases (LPPs) are a class of enzymes that can dephosphorylate a number of lysophopholipids in vitro. Analysis of knockouts of LPP family members has demonstrated striking but diverse developmental roles for these enzymes. LPP3 is required for mouse vascular development while th...

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Bibliographic Details
Published in:Fly (Austin, Tex.) Tex.), 2013-01, Vol.7 (1), p.18-22
Main Authors: Ile, Kristina E., Renault, Andrew D.
Format: Article
Language:English
Subjects:
Animals
barrier
Drosophila
Drosophila - embryology
Drosophila - metabolism
Drosophila - ultrastructure
Drosophila Proteins - metabolism
Drosophila Proteins - physiology
Embryo, Nonmammalian - metabolism
Embryo, Nonmammalian - ultrastructure
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Lysophospholipids - chemistry
Lysophospholipids - metabolism
Membrane Proteins - metabolism
Membrane Proteins - physiology
Particle Size
Permeability
Phosphatidate Phosphatase - metabolism
Phosphatidate Phosphatase - physiology
Phosphorylation
septate junction
Serpentine
trachea
Trachea - embryology
Trachea - metabolism
Trachea - ultrastructure
Vermiform
Wunen
Wunen2
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Summary:Lipid phosphate phosphatases (LPPs) are a class of enzymes that can dephosphorylate a number of lysophopholipids in vitro. Analysis of knockouts of LPP family members has demonstrated striking but diverse developmental roles for these enzymes. LPP3 is required for mouse vascular development while the Drosophila LPPs Wunen (Wun) and Wunen2 (Wun2) are required during embryogenesis for germ cell migration and survival. In a recent publication we examined if these fly LPPs have further developmental roles and found that Wun is required for proper tracheal formation. In particular we highlight a role for Wun in septate junction mediated barrier function in the tracheal system. In this paper we discuss further the possible mechanisms by which LPPs may influence barrier activity.
ISSN:1933-6934
1933-6942
DOI:10.4161/fly.22938