Genetic visualization of notch signaling in mammalian neurogenesis

Notch signaling plays crucial roles in fate determination and the differentiation of neural stem cells in embryonic and adult brains. It is now clear that the notch pathway is under more complex and dynamic regulation than previously thought. To understand the functional details of notch signaling m...

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 2013-06, Vol.70 (12), p.2045-2057
Main Authors: Imayoshi, Itaru, Shimojo, Hiromi, Sakamoto, Masayuki, Ohtsuka, Toshiyuki, Kageyama, Ryoichiro
Format: Article
Language:English
Subjects:
Animals
beta-Galactosidase
Biochemistry
Biomedical and Life Sciences
Biomedicine
Brain
Brain - embryology
Brain - growth & development
Cell Biology
Cellular biology
Enzymes
Gene Expression Regulation - genetics
Gene Expression Regulation - physiology
Genetics
Green Fluorescent Proteins
Humans
Life Sciences
Luciferases
Mice
Mice, Transgenic
Models, Biological
Neurogenesis - genetics
Neurogenesis - physiology
Neurology
Receptors, Notch - genetics
Receptors, Notch - metabolism
Review
Signal Transduction - genetics
Signal Transduction - physiology
Stem cells
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Summary:Notch signaling plays crucial roles in fate determination and the differentiation of neural stem cells in embryonic and adult brains. It is now clear that the notch pathway is under more complex and dynamic regulation than previously thought. To understand the functional details of notch signaling more precisely, it is important to reveal when, where, and how notch signaling is dynamically communicated between cells, for which the visualization of notch signaling is essential. In this review, we introduce recent technical advances in the visualization of notch signaling during neural development and in the adult brain, and we discuss the physiological significance of dynamic regulation of notch signaling.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-012-1151-x