Targeting self-renewal pathways in myeloid malignancies

A fundamental property of hematopoietic stem cells (HSCs) is the ability to self-renew. This is a complex process involving multiple signal transduction cascades which control the fine balance between self-renewal and differentiation through transcriptional networks. Key activators/regulators of sel...

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Bibliographic Details
Published in:Cell communication and signaling 2013-05, Vol.11 (1), p.33-33, Article 33
Main Authors: Sands, William A, Copland, Mhairi, Wheadon, Helen
Format: Article
Language:English
Subjects:
Cellular signal transduction
Chemotherapy
Cytokines
Disease
Hematopoietic stem cells
Leukemia
Life sciences
Ligands
Population
Proteins
Review
Signal transduction
Stem cells
Transplantation
Vascular endothelial growth factor
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Summary:A fundamental property of hematopoietic stem cells (HSCs) is the ability to self-renew. This is a complex process involving multiple signal transduction cascades which control the fine balance between self-renewal and differentiation through transcriptional networks. Key activators/regulators of self-renewal include chemokines, cytokines and morphogens which are expressed in the bone marrow niche, either in a paracrine or autocrine fashion, and modulate stem cell behaviour. Increasing evidence suggests that the downstream signaling pathways induced by these ligands converge at multiple levels providing a degree of redundancy in steady state hematopoiesis. Here we will focus on how these pathways cross-talk to regulate HSC self-renewal highlighting potential therapeutic windows which could be targeted to prevent leukemic stem cell self-renewal in myeloid malignancies.
ISSN:1478-811X
1478-811X
DOI:10.1186/1478-811x-11-33