Decreased retinal–choroidal blood flow in retinitis pigmentosa as measured by MRI

Purpose To evaluate retinal and choroidal blood flow (BF) using high-resolution magnetic resonance imaging (MRI) as well as visual function measured by the electroretinogram (ERG) in patients with retinitis pigmentosa (RP). Methods MRI studies were performed in 6 RP patients (29–67 years) and 5 heal...

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Bibliographic Details
Published in:Documenta ophthalmologica 2013-06, Vol.126 (3), p.187-197
Main Authors: Zhang, Yi, Harrison, Joseph M., Nateras, Oscar San Emeterio, Chalfin, Steven, Duong, Timothy Q.
Format: Article
Language:English
Subjects:
Adult
Aged
Choroid - blood supply
Choroid - physiopathology
Electroretinography
Female
Humans
Magnetic Resonance Imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Ophthalmology
Original Research Article
Regional Blood Flow - physiology
Retina - physiopathology
Retinitis Pigmentosa - diagnosis
Retinitis Pigmentosa - physiopathology
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Summary:Purpose To evaluate retinal and choroidal blood flow (BF) using high-resolution magnetic resonance imaging (MRI) as well as visual function measured by the electroretinogram (ERG) in patients with retinitis pigmentosa (RP). Methods MRI studies were performed in 6 RP patients (29–67 years) and 5 healthy volunteers (29–64 years) on a 3-Tesla scanner with a custom-made surface coil. Quantitative BF was measured using the pseudo-continuous arterial spin-labeling technique at 0.5 × 0.8 × 6.0 mm. Full-field ERGs of all patients were recorded. Amplitudes and implicit times of standard ERGs were analyzed. Results Basal BF in the posterior retinal-choroid was 142 ± 16 ml/100ml/min (or 1.14 ± 0.13 μl/mm 2 /min) in the control group and was 70 ±19 ml/100ml/min (or 0.56 ± 0.15 μl/mm 2 /min) in the RP group. Retinal–choroidal BF was significantly reduced by 52 ± 8 % in RP patients compared to controls ( P
ISSN:0012-4486
1573-2622
DOI:10.1007/s10633-013-9374-1