Isoniazid-Induced Severe Hepatotoxicity: An Infrequent but Preventable Cause of Liver Failure in Children Treated for Latent Tuberculosis Infection

Isoniazid (INH) monotherapy has gained widespread acceptance as an efficacious therapy for latent tuberculosis infection (LTBI) especially in low-prevalence settings. Although INH related hepatotoxicity is well recognized, progression to severe liver dysfunction requiring care at a transplant center...

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Bibliographic Details
Published in:Clinical Medicine Insights: Pediatrics 2011-01, Vol.2011 (2011), p.9-13
Main Authors: Desrochers, Dan, González-Peralta, Regino P., McClenathan, Daniel T., Wilsey, Michael J., Haafiz, Allah
Format: Article
Language:English
Subjects:
Case Report
Children
Health aspects
Isoniazid
Liver failure
Skin
Tuberculosis
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Summary:Isoniazid (INH) monotherapy has gained widespread acceptance as an efficacious therapy for latent tuberculosis infection (LTBI) especially in low-prevalence settings. Although INH related hepatotoxicity is well recognized, progression to severe liver dysfunction requiring care at a transplant center remains unpredictable. We report the management of a five year-old girl who developed progressive liver failure due to INH prophylaxis. This highlights the potential severity of INH related hepatic injury and underscores the significance of vigilant clinical monitoring throughout the duration of the therapy in children.
ISSN:1179-5565
1179-5565
DOI:10.4137/CMPed.S6406