Brazilian Propolis Antileishmanial and Immunomodulatory Effects

The antileishmanial and immunomodulatory effects of propolis collected in Botucatu, São Paulo State, Brazil, were evaluated in Leishmania (Viannia) braziliensis experimental infection. The antileishmanial effect of propolis on promastigote forms was verified by reducing growth and by promoting morph...

Full description

Saved in:
Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2013-01, Vol.2013 (2013), p.1-7
Main Authors: da Silva, Suelen Santos, Thomé, Graciele da Silva, Cataneo, Allan Henrique Depieri, Miranda, Milena Menegazzo, Felipe, Ionice, Andrade, Célia Guadalupe Tardeli de Jesus, Watanabe, Maria Angélica Ehara, Piana, Gilce Maria, Sforcin, José Maurício, Pavanelli, Wander Rogério, Conchon-Costa, Ivete
Format: Article
Language:English
Subjects:
Cell activation
Cytokines
Drugs
Enzyme-linked immunosorbent assay
Essential oils
Ethanol
Experimental infection
Exudation
Flavonoids
Hepatocytes
Immunology
Immunomodulation
Immunomodulators
Infections
Interleukin 12
Leishmania
Liver
Macrophages
Mice
Parasites
Parasitic diseases
Parasitology
Peritoneum
Phenols
Promastigotes
Propolis
Rodents
Scanning electron microscopy
Solvents
Triterpenes
Tumor necrosis factor
Viannia braziliensis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c499t-59f4d74550fab21a767f2f64423499db773a417f4953f76624b536ed197ec8a03
cites cdi_FETCH-LOGICAL-c499t-59f4d74550fab21a767f2f64423499db773a417f4953f76624b536ed197ec8a03
container_end_page 7
container_issue 2013
container_start_page 1
container_title Evidence-based complementary and alternative medicine
container_volume 2013
creator da Silva, Suelen Santos
Thomé, Graciele da Silva
Cataneo, Allan Henrique Depieri
Miranda, Milena Menegazzo
Felipe, Ionice
Andrade, Célia Guadalupe Tardeli de Jesus
Watanabe, Maria Angélica Ehara
Piana, Gilce Maria
Sforcin, José Maurício
Pavanelli, Wander Rogério
Conchon-Costa, Ivete
description The antileishmanial and immunomodulatory effects of propolis collected in Botucatu, São Paulo State, Brazil, were evaluated in Leishmania (Viannia) braziliensis experimental infection. The antileishmanial effect of propolis on promastigote forms was verified by reducing growth and by promoting morphologic alterations observed by scanning electron microscopy. In in vitro immunomodulatory assays, macrophages were pretreated with propolis and then infected with L. (V.) braziliensis. In vivo, supernatants from liver cells and peritoneal exudate of BALB/c mice pretreated with propolis and infected with Leishmania (107/mL promastigotes) were collected, and TNF-α and IL-12 were measured by ELISA. Macrophages incubated with propolis showed a significant increase in interiorization and further killing of parasites. An increased TNF-α production was seen in mice pretreated with propolis, whereas IL-12 was downregulated during the infection. In conclusion, Brazilian propolis showed a direct action on the parasite and displayed immunomodulatory effects on murine macrophages, even though the parasite has been reported to affect the activation pathways of the cell. The observed effects could be associated with the presence of phenolic compounds (flavonoids, aromatic acids, and benzopyranes), di- and triterpenes, and essential oils found in our propolis sample.
doi_str_mv 10.1155/2013/673058
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3670560</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3894098601</sourcerecordid><originalsourceid>FETCH-LOGICAL-c499t-59f4d74550fab21a767f2f64423499db773a417f4953f76624b536ed197ec8a03</originalsourceid><addsrcrecordid>eNqF0c1rFDEYBvAgiv3Qk2dlwEtR1ub7TS5KLVULBT0oeAvZmcRNySRrMqPUv94sUxf10lMC74-HN3kQekLwK0KEOKWYsFMJDAt1Dx0S4GTFqVL393f4eoCOar3GmGoAeIgOKANJiaCH6M3bYn-FGGzqPpW8zTHU7ixNIbpQN6NNwcbOpqG7HMc55TEPc7RTLjfdhfeun-oj9MDbWN3j2_MYfXl38fn8w-rq4_vL87OrVc-1nlZCez4AFwJ7u6bEggRPveScsjYf1gDMcgKea8E8SEn5WjDpBqLB9cpidoxeL7nbeT26oXdpKjaabQmjLTcm22D-naSwMd_yD8MkYCF3ASe3ASV_n12dzBhq72K0yeW5GtJWUFRhEHfTlqlAY6kbff4fvc5zSe0nWiBXQnFKeFMvF9WXXGtxfr83wWbXodl1aJYOm37291P39k9pDbxYwCakwf4Md6Q9XbBrxHm7x1xpJoD9Bk6_rDw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1748584214</pqid></control><display><type>article</type><title>Brazilian Propolis Antileishmanial and Immunomodulatory Effects</title><source>Open Access: Wiley-Blackwell Open Access Journals</source><source>Publicly Available Content (ProQuest)</source><creator>da Silva, Suelen Santos ; Thomé, Graciele da Silva ; Cataneo, Allan Henrique Depieri ; Miranda, Milena Menegazzo ; Felipe, Ionice ; Andrade, Célia Guadalupe Tardeli de Jesus ; Watanabe, Maria Angélica Ehara ; Piana, Gilce Maria ; Sforcin, José Maurício ; Pavanelli, Wander Rogério ; Conchon-Costa, Ivete</creator><contributor>Bankova, Vassya ; Vassya Bankova</contributor><creatorcontrib>da Silva, Suelen Santos ; Thomé, Graciele da Silva ; Cataneo, Allan Henrique Depieri ; Miranda, Milena Menegazzo ; Felipe, Ionice ; Andrade, Célia Guadalupe Tardeli de Jesus ; Watanabe, Maria Angélica Ehara ; Piana, Gilce Maria ; Sforcin, José Maurício ; Pavanelli, Wander Rogério ; Conchon-Costa, Ivete ; Bankova, Vassya ; Vassya Bankova</creatorcontrib><description>The antileishmanial and immunomodulatory effects of propolis collected in Botucatu, São Paulo State, Brazil, were evaluated in Leishmania (Viannia) braziliensis experimental infection. The antileishmanial effect of propolis on promastigote forms was verified by reducing growth and by promoting morphologic alterations observed by scanning electron microscopy. In in vitro immunomodulatory assays, macrophages were pretreated with propolis and then infected with L. (V.) braziliensis. In vivo, supernatants from liver cells and peritoneal exudate of BALB/c mice pretreated with propolis and infected with Leishmania (107/mL promastigotes) were collected, and TNF-α and IL-12 were measured by ELISA. Macrophages incubated with propolis showed a significant increase in interiorization and further killing of parasites. An increased TNF-α production was seen in mice pretreated with propolis, whereas IL-12 was downregulated during the infection. In conclusion, Brazilian propolis showed a direct action on the parasite and displayed immunomodulatory effects on murine macrophages, even though the parasite has been reported to affect the activation pathways of the cell. The observed effects could be associated with the presence of phenolic compounds (flavonoids, aromatic acids, and benzopyranes), di- and triterpenes, and essential oils found in our propolis sample.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2013/673058</identifier><identifier>PMID: 23762152</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Cell activation ; Cytokines ; Drugs ; Enzyme-linked immunosorbent assay ; Essential oils ; Ethanol ; Experimental infection ; Exudation ; Flavonoids ; Hepatocytes ; Immunology ; Immunomodulation ; Immunomodulators ; Infections ; Interleukin 12 ; Leishmania ; Liver ; Macrophages ; Mice ; Parasites ; Parasitic diseases ; Parasitology ; Peritoneum ; Phenols ; Promastigotes ; Propolis ; Rodents ; Scanning electron microscopy ; Solvents ; Triterpenes ; Tumor necrosis factor ; Viannia braziliensis</subject><ispartof>Evidence-based complementary and alternative medicine, 2013-01, Vol.2013 (2013), p.1-7</ispartof><rights>Copyright © 2013 Suelen Santos da Silva et al.</rights><rights>Copyright © 2013 Suelen Santos da Silva et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2013 Suelen Santos da Silva et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-59f4d74550fab21a767f2f64423499db773a417f4953f76624b536ed197ec8a03</citedby><cites>FETCH-LOGICAL-c499t-59f4d74550fab21a767f2f64423499db773a417f4953f76624b536ed197ec8a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1748584214/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1748584214?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,25753,27924,27925,37012,37013,44590,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23762152$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bankova, Vassya</contributor><contributor>Vassya Bankova</contributor><creatorcontrib>da Silva, Suelen Santos</creatorcontrib><creatorcontrib>Thomé, Graciele da Silva</creatorcontrib><creatorcontrib>Cataneo, Allan Henrique Depieri</creatorcontrib><creatorcontrib>Miranda, Milena Menegazzo</creatorcontrib><creatorcontrib>Felipe, Ionice</creatorcontrib><creatorcontrib>Andrade, Célia Guadalupe Tardeli de Jesus</creatorcontrib><creatorcontrib>Watanabe, Maria Angélica Ehara</creatorcontrib><creatorcontrib>Piana, Gilce Maria</creatorcontrib><creatorcontrib>Sforcin, José Maurício</creatorcontrib><creatorcontrib>Pavanelli, Wander Rogério</creatorcontrib><creatorcontrib>Conchon-Costa, Ivete</creatorcontrib><title>Brazilian Propolis Antileishmanial and Immunomodulatory Effects</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>The antileishmanial and immunomodulatory effects of propolis collected in Botucatu, São Paulo State, Brazil, were evaluated in Leishmania (Viannia) braziliensis experimental infection. The antileishmanial effect of propolis on promastigote forms was verified by reducing growth and by promoting morphologic alterations observed by scanning electron microscopy. In in vitro immunomodulatory assays, macrophages were pretreated with propolis and then infected with L. (V.) braziliensis. In vivo, supernatants from liver cells and peritoneal exudate of BALB/c mice pretreated with propolis and infected with Leishmania (107/mL promastigotes) were collected, and TNF-α and IL-12 were measured by ELISA. Macrophages incubated with propolis showed a significant increase in interiorization and further killing of parasites. An increased TNF-α production was seen in mice pretreated with propolis, whereas IL-12 was downregulated during the infection. In conclusion, Brazilian propolis showed a direct action on the parasite and displayed immunomodulatory effects on murine macrophages, even though the parasite has been reported to affect the activation pathways of the cell. The observed effects could be associated with the presence of phenolic compounds (flavonoids, aromatic acids, and benzopyranes), di- and triterpenes, and essential oils found in our propolis sample.</description><subject>Cell activation</subject><subject>Cytokines</subject><subject>Drugs</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Essential oils</subject><subject>Ethanol</subject><subject>Experimental infection</subject><subject>Exudation</subject><subject>Flavonoids</subject><subject>Hepatocytes</subject><subject>Immunology</subject><subject>Immunomodulation</subject><subject>Immunomodulators</subject><subject>Infections</subject><subject>Interleukin 12</subject><subject>Leishmania</subject><subject>Liver</subject><subject>Macrophages</subject><subject>Mice</subject><subject>Parasites</subject><subject>Parasitic diseases</subject><subject>Parasitology</subject><subject>Peritoneum</subject><subject>Phenols</subject><subject>Promastigotes</subject><subject>Propolis</subject><subject>Rodents</subject><subject>Scanning electron microscopy</subject><subject>Solvents</subject><subject>Triterpenes</subject><subject>Tumor necrosis factor</subject><subject>Viannia braziliensis</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNqF0c1rFDEYBvAgiv3Qk2dlwEtR1ub7TS5KLVULBT0oeAvZmcRNySRrMqPUv94sUxf10lMC74-HN3kQekLwK0KEOKWYsFMJDAt1Dx0S4GTFqVL393f4eoCOar3GmGoAeIgOKANJiaCH6M3bYn-FGGzqPpW8zTHU7ixNIbpQN6NNwcbOpqG7HMc55TEPc7RTLjfdhfeun-oj9MDbWN3j2_MYfXl38fn8w-rq4_vL87OrVc-1nlZCez4AFwJ7u6bEggRPveScsjYf1gDMcgKea8E8SEn5WjDpBqLB9cpidoxeL7nbeT26oXdpKjaabQmjLTcm22D-naSwMd_yD8MkYCF3ASe3ASV_n12dzBhq72K0yeW5GtJWUFRhEHfTlqlAY6kbff4fvc5zSe0nWiBXQnFKeFMvF9WXXGtxfr83wWbXodl1aJYOm37291P39k9pDbxYwCakwf4Md6Q9XbBrxHm7x1xpJoD9Bk6_rDw</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>da Silva, Suelen Santos</creator><creator>Thomé, Graciele da Silva</creator><creator>Cataneo, Allan Henrique Depieri</creator><creator>Miranda, Milena Menegazzo</creator><creator>Felipe, Ionice</creator><creator>Andrade, Célia Guadalupe Tardeli de Jesus</creator><creator>Watanabe, Maria Angélica Ehara</creator><creator>Piana, Gilce Maria</creator><creator>Sforcin, José Maurício</creator><creator>Pavanelli, Wander Rogério</creator><creator>Conchon-Costa, Ivete</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>M7N</scope><scope>5PM</scope></search><sort><creationdate>20130101</creationdate><title>Brazilian Propolis Antileishmanial and Immunomodulatory Effects</title><author>da Silva, Suelen Santos ; Thomé, Graciele da Silva ; Cataneo, Allan Henrique Depieri ; Miranda, Milena Menegazzo ; Felipe, Ionice ; Andrade, Célia Guadalupe Tardeli de Jesus ; Watanabe, Maria Angélica Ehara ; Piana, Gilce Maria ; Sforcin, José Maurício ; Pavanelli, Wander Rogério ; Conchon-Costa, Ivete</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-59f4d74550fab21a767f2f64423499db773a417f4953f76624b536ed197ec8a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Cell activation</topic><topic>Cytokines</topic><topic>Drugs</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Essential oils</topic><topic>Ethanol</topic><topic>Experimental infection</topic><topic>Exudation</topic><topic>Flavonoids</topic><topic>Hepatocytes</topic><topic>Immunology</topic><topic>Immunomodulation</topic><topic>Immunomodulators</topic><topic>Infections</topic><topic>Interleukin 12</topic><topic>Leishmania</topic><topic>Liver</topic><topic>Macrophages</topic><topic>Mice</topic><topic>Parasites</topic><topic>Parasitic diseases</topic><topic>Parasitology</topic><topic>Peritoneum</topic><topic>Phenols</topic><topic>Promastigotes</topic><topic>Propolis</topic><topic>Rodents</topic><topic>Scanning electron microscopy</topic><topic>Solvents</topic><topic>Triterpenes</topic><topic>Tumor necrosis factor</topic><topic>Viannia braziliensis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>da Silva, Suelen Santos</creatorcontrib><creatorcontrib>Thomé, Graciele da Silva</creatorcontrib><creatorcontrib>Cataneo, Allan Henrique Depieri</creatorcontrib><creatorcontrib>Miranda, Milena Menegazzo</creatorcontrib><creatorcontrib>Felipe, Ionice</creatorcontrib><creatorcontrib>Andrade, Célia Guadalupe Tardeli de Jesus</creatorcontrib><creatorcontrib>Watanabe, Maria Angélica Ehara</creatorcontrib><creatorcontrib>Piana, Gilce Maria</creatorcontrib><creatorcontrib>Sforcin, José Maurício</creatorcontrib><creatorcontrib>Pavanelli, Wander Rogério</creatorcontrib><creatorcontrib>Conchon-Costa, Ivete</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing &amp; Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Psychology Database (ProQuest)</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>da Silva, Suelen Santos</au><au>Thomé, Graciele da Silva</au><au>Cataneo, Allan Henrique Depieri</au><au>Miranda, Milena Menegazzo</au><au>Felipe, Ionice</au><au>Andrade, Célia Guadalupe Tardeli de Jesus</au><au>Watanabe, Maria Angélica Ehara</au><au>Piana, Gilce Maria</au><au>Sforcin, José Maurício</au><au>Pavanelli, Wander Rogério</au><au>Conchon-Costa, Ivete</au><au>Bankova, Vassya</au><au>Vassya Bankova</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brazilian Propolis Antileishmanial and Immunomodulatory Effects</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>2013</volume><issue>2013</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>The antileishmanial and immunomodulatory effects of propolis collected in Botucatu, São Paulo State, Brazil, were evaluated in Leishmania (Viannia) braziliensis experimental infection. The antileishmanial effect of propolis on promastigote forms was verified by reducing growth and by promoting morphologic alterations observed by scanning electron microscopy. In in vitro immunomodulatory assays, macrophages were pretreated with propolis and then infected with L. (V.) braziliensis. In vivo, supernatants from liver cells and peritoneal exudate of BALB/c mice pretreated with propolis and infected with Leishmania (107/mL promastigotes) were collected, and TNF-α and IL-12 were measured by ELISA. Macrophages incubated with propolis showed a significant increase in interiorization and further killing of parasites. An increased TNF-α production was seen in mice pretreated with propolis, whereas IL-12 was downregulated during the infection. In conclusion, Brazilian propolis showed a direct action on the parasite and displayed immunomodulatory effects on murine macrophages, even though the parasite has been reported to affect the activation pathways of the cell. The observed effects could be associated with the presence of phenolic compounds (flavonoids, aromatic acids, and benzopyranes), di- and triterpenes, and essential oils found in our propolis sample.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>23762152</pmid><doi>10.1155/2013/673058</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1741-427X
ispartof Evidence-based complementary and alternative medicine, 2013-01, Vol.2013 (2013), p.1-7
issn 1741-427X
1741-4288
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3670560
source Open Access: Wiley-Blackwell Open Access Journals; Publicly Available Content (ProQuest)
subjects Cell activation
Cytokines
Drugs
Enzyme-linked immunosorbent assay
Essential oils
Ethanol
Experimental infection
Exudation
Flavonoids
Hepatocytes
Immunology
Immunomodulation
Immunomodulators
Infections
Interleukin 12
Leishmania
Liver
Macrophages
Mice
Parasites
Parasitic diseases
Parasitology
Peritoneum
Phenols
Promastigotes
Propolis
Rodents
Scanning electron microscopy
Solvents
Triterpenes
Tumor necrosis factor
Viannia braziliensis
title Brazilian Propolis Antileishmanial and Immunomodulatory Effects
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T18%3A41%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Brazilian%20Propolis%20Antileishmanial%20and%20Immunomodulatory%20Effects&rft.jtitle=Evidence-based%20complementary%20and%20alternative%20medicine&rft.au=da%20Silva,%20Suelen%20Santos&rft.date=2013-01-01&rft.volume=2013&rft.issue=2013&rft.spage=1&rft.epage=7&rft.pages=1-7&rft.issn=1741-427X&rft.eissn=1741-4288&rft_id=info:doi/10.1155/2013/673058&rft_dat=%3Cproquest_pubme%3E3894098601%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c499t-59f4d74550fab21a767f2f64423499db773a417f4953f76624b536ed197ec8a03%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1748584214&rft_id=info:pmid/23762152&rfr_iscdi=true