Expression and distribution of dendritic cells in nasal polyps

The aim of the present study was to investigate the expression, distribution and function of dendritic cells (DCs) and to study their role in nasal polyps. The study involved 55 participants, 45 of whom had nasal polyps and were the study group and 10 who had normal inferior turbinates and were the...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2013-05, Vol.5 (5), p.1476-1480
Main Authors: LIN, XIN-SHENG, LUO, XIAN-YANG, WANG, HUI-GE, LI, CHUANG-WEI, LIN, XIN, YAN, CHU
Format: Article
Language:English
Subjects:
Antigens
Biotechnology
CD1a
CD40
Cytokines
Cytoplasm
Dendritic cells
Lymphocytes
Methods
nasal polyps
Pathogenesis
Proteins
S-100 protein
Surgery
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Summary:The aim of the present study was to investigate the expression, distribution and function of dendritic cells (DCs) and to study their role in nasal polyps. The study involved 55 participants, 45 of whom had nasal polyps and were the study group and 10 who had normal inferior turbinates and were the control group. Immunohistochemical staining was used to visualize the expression and distribution of the S-100 protein. A double immunostaining method was used to visualize the CD1a and CD40 expression and the images were analyzed with Axioplan 2 microscopy. The expression level of the S-100 protein in the nasal polyps was higher than that in the normal inferior turbinates with a significant difference (P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2013.986