A multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data

Intussusception (IS) is a form of acute intestinal obstruction that occurs mainly in infants and is usually of unknown cause. An association between IS and the first licensed rotavirus vaccine, a reassortant-tetravalent, rhesus-based rotavirus vaccine (RRV-TV), led to the withdrawal of the vaccine....

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Published in:BMC gastroenterology 2013-05, Vol.13 (1), p.95-95, Article 95
Main Authors: Sáez-Llorens, Xavier, Velázquez, F Raúl, Lopez, Pio, Espinoza, Felix, Linhares, Alexandre C, Abate, Hector, Nuñez, Ernesto, Venegas, Guillermo, Vergara, Rodrigo, Jimenez, Ana L, Rivera, Maribel, Aranza, Carlos, Richardson, Vesta, Macias-Parra, Mercedes, Palacios, Guillermo Ruiz, Rivera, Luis, Ortega-Barria, Eduardo, Cervantes, Yolanda, Rüttimann, Ricardo, Rubio, Pilar, Acosta, Camilo J, Newbern, Claire, Verstraeten, Thomas, Breuer, Thomas
Format: Article
Language:English
Subjects:
Analysis
Child, Preschool
Cross-Sectional Studies
Female
Gastroenterology
Humans
Incidence
Infant
Infants
Intestines
Intussusception
Intussusception - epidemiology
Intussusception - surgery
Latin America - epidemiology
Male
Prospective Studies
Rotavirus Vaccines
Vaccination
Viral vaccines
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Summary:Intussusception (IS) is a form of acute intestinal obstruction that occurs mainly in infants and is usually of unknown cause. An association between IS and the first licensed rotavirus vaccine, a reassortant-tetravalent, rhesus-based rotavirus vaccine (RRV-TV), led to the withdrawal of the vaccine. New rotavirus vaccines have now been developed and extensively studied for their potential association with IS. This study aimed to describe the epidemiology and to estimate the incidence of IS in Latin American infants prior to new vaccine introduction. Children under 2 years of age representing potential IS cases were enrolled in 16 centers in 11 Latin American countries from January 2003 to May 2005. IS cases were classified as definite, probable, possible or suspected as stated on the Brighton Collaboration Working Group guidelines. From 517 potential cases identified, 476 (92%) cases were classified as definite, 21 probable, 10 possible and 10 suspected for intussusception. Among the 476 definite IS cases, the median age at presentation was 6.4 months with 89% of cases aged
ISSN:1471-230X
1471-230X
DOI:10.1186/1471-230X-13-95