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A sex-specific transcription factor controls male identity in a simultaneous hermaphrodite
Evolutionary transitions between hermaphroditic and dioecious reproductive states are found in many groups of animals. To understand such transitions, it is important to characterize diverse modes of sex determination utilized by metazoans. Currently, little is known about how simultaneous hermaphro...
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| Published in: | Nature communications 2013, Vol.4 (1), p.1814-1814, Article 1814 |
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| creator | Chong, Tracy Collins, James J. Brubacher, John L. Zarkower, David Newmark, Phillip A. |
| description | Evolutionary transitions between hermaphroditic and dioecious reproductive states are found in many groups of animals. To understand such transitions, it is important to characterize diverse modes of sex determination utilized by metazoans. Currently, little is known about how simultaneous hermaphrodites specify and maintain male and female organs in a single individual. Here we show that a sex-specific gene,
Smed-dmd-1
encoding a predicted doublesex/male-abnormal-3 (DM) domain transcription factor, is required for specification of male germ cells in a simultaneous hermaphrodite, the planarian
Schmidtea mediterranea
.
dmd-1
has a male-specific role in the maintenance and regeneration of the testes and male accessory reproductive organs. In addition, a homologue of
dmd-1
exhibits male-specific expression in
Schistosoma mansoni
, a derived, dioecious flatworm. These results demonstrate conservation of the role of DM domain genes in sexual development in lophotrochozoans and suggest one means by which modulation of sex-specific pathways can drive the transition from hermaphroditism to dioecy.
Hermaphrodites develop and maintain male and female reproductive organs in a single individual. Chong
et al
. show that a DM domain transcription factor is required for male germ cell regeneration and maintains ‘maleness’ in a hermaphrodite, the planarian flatworm
Schmidtea mediterranea
. |
| doi_str_mv | 10.1038/ncomms2811 |
| format | article |
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Smed-dmd-1
encoding a predicted doublesex/male-abnormal-3 (DM) domain transcription factor, is required for specification of male germ cells in a simultaneous hermaphrodite, the planarian
Schmidtea mediterranea
.
dmd-1
has a male-specific role in the maintenance and regeneration of the testes and male accessory reproductive organs. In addition, a homologue of
dmd-1
exhibits male-specific expression in
Schistosoma mansoni
, a derived, dioecious flatworm. These results demonstrate conservation of the role of DM domain genes in sexual development in lophotrochozoans and suggest one means by which modulation of sex-specific pathways can drive the transition from hermaphroditism to dioecy.
Hermaphrodites develop and maintain male and female reproductive organs in a single individual. Chong
et al
. show that a DM domain transcription factor is required for male germ cell regeneration and maintains ‘maleness’ in a hermaphrodite, the planarian flatworm
Schmidtea mediterranea
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Smed-dmd-1
encoding a predicted doublesex/male-abnormal-3 (DM) domain transcription factor, is required for specification of male germ cells in a simultaneous hermaphrodite, the planarian
Schmidtea mediterranea
.
dmd-1
has a male-specific role in the maintenance and regeneration of the testes and male accessory reproductive organs. In addition, a homologue of
dmd-1
exhibits male-specific expression in
Schistosoma mansoni
, a derived, dioecious flatworm. These results demonstrate conservation of the role of DM domain genes in sexual development in lophotrochozoans and suggest one means by which modulation of sex-specific pathways can drive the transition from hermaphroditism to dioecy.
Hermaphrodites develop and maintain male and female reproductive organs in a single individual. Chong
et al
. show that a DM domain transcription factor is required for male germ cell regeneration and maintains ‘maleness’ in a hermaphrodite, the planarian flatworm
Schmidtea mediterranea
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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chong, Tracy</au><au>Collins, James J.</au><au>Brubacher, John L.</au><au>Zarkower, David</au><au>Newmark, Phillip A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A sex-specific transcription factor controls male identity in a simultaneous hermaphrodite</atitle><jtitle>Nature communications</jtitle><stitle>Nat Commun</stitle><addtitle>Nat Commun</addtitle><date>2013</date><risdate>2013</risdate><volume>4</volume><issue>1</issue><spage>1814</spage><epage>1814</epage><pages>1814-1814</pages><artnum>1814</artnum><issn>2041-1723</issn><eissn>2041-1723</eissn><abstract>Evolutionary transitions between hermaphroditic and dioecious reproductive states are found in many groups of animals. To understand such transitions, it is important to characterize diverse modes of sex determination utilized by metazoans. Currently, little is known about how simultaneous hermaphrodites specify and maintain male and female organs in a single individual. Here we show that a sex-specific gene,
Smed-dmd-1
encoding a predicted doublesex/male-abnormal-3 (DM) domain transcription factor, is required for specification of male germ cells in a simultaneous hermaphrodite, the planarian
Schmidtea mediterranea
.
dmd-1
has a male-specific role in the maintenance and regeneration of the testes and male accessory reproductive organs. In addition, a homologue of
dmd-1
exhibits male-specific expression in
Schistosoma mansoni
, a derived, dioecious flatworm. These results demonstrate conservation of the role of DM domain genes in sexual development in lophotrochozoans and suggest one means by which modulation of sex-specific pathways can drive the transition from hermaphroditism to dioecy.
Hermaphrodites develop and maintain male and female reproductive organs in a single individual. Chong
et al
. show that a DM domain transcription factor is required for male germ cell regeneration and maintains ‘maleness’ in a hermaphrodite, the planarian flatworm
Schmidtea mediterranea
.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23652002</pmid><doi>10.1038/ncomms2811</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Nature communications, 2013, Vol.4 (1), p.1814-1814, Article 1814 |
| issn | 2041-1723 2041-1723 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3674237 |
| source | Publicly Available Content Database (Proquest) (PQ_SDU_P3); Springer Nature - Connect here FIRST to enable access; PubMed Central; Springer Nature - nature.com Journals - Fully Open Access |
| subjects | 631/136 631/181 Animals Brain - cytology Brain - metabolism Cell Differentiation - genetics Disorders of Sex Development - genetics Disorders of Sex Development - metabolism Domains Female Females Gene Expression Regulation Genes, Helminth - genetics Genitalia, Male - cytology Genitalia, Male - metabolism Germ cells Germ Cells - cytology Germ Cells - metabolism Hermaphrodites Hermaphroditism Homology Humanities and Social Sciences Male Males Molecular Sequence Data multidisciplinary Neurons - cytology Neurons - metabolism Organs Planarians - cytology Planarians - genetics Planarians - metabolism Regeneration Regeneration - genetics Reproduction, Asexual - genetics Reproductive organs Schmidtea mediterranea Science Science (multidisciplinary) Sequence Homology, Amino Acid Sex Sex Characteristics Sex determination Transcription factors Transcription Factors - metabolism |
| title | A sex-specific transcription factor controls male identity in a simultaneous hermaphrodite |
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