Short-term depression of external globus pallidus-subthalamic nucleus synaptic transmission and implications for patterning subthalamic activity

The frequency and pattern of activity in the reciprocally connected GABAergic external globus pallidus (GPe) and glutamatergic subthalamic nucleus (STN) are closely related to motor function. Although phasic, unitary GPe-STN inputs powerfully pattern STN activity ex vivo, correlated GPe-STN activity...

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Bibliographic Details
Published in:The Journal of neuroscience 2013-04, Vol.33 (17), p.7130-7144
Main Authors: Atherton, Jeremy F, Menard, Ariane, Urbain, Nadia, Bevan, Mark D
Format: Article
Language:English
Subjects:
Animals
Globus Pallidus - physiology
Male
Mice
Mice, Inbred C57BL
Organ Culture Techniques
Random Allocation
Rats
Rats, Sprague-Dawley
Subthalamic Nucleus - physiology
Synaptic Transmission - physiology
Time Factors
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Summary:The frequency and pattern of activity in the reciprocally connected GABAergic external globus pallidus (GPe) and glutamatergic subthalamic nucleus (STN) are closely related to motor function. Although phasic, unitary GPe-STN inputs powerfully pattern STN activity ex vivo, correlated GPe-STN activity is not normally observed in vivo. To test the hypothesis that the GPe's influence is constrained by short-term synaptic depression, unitary GPe-STN inputs were stimulated in rat and mouse brain slices at rates and in patterns that mimicked GPe activity in vivo. Together with connectivity estimates these data were then used to simulate GPe-STN transmission. Unitary GPe-STN synaptic connections initially generated large conductances and transmitted reliably. However, the amplitude and reliability of transmission declined rapidly (τ = 0.6 ± 0.5 s) to
ISSN:0270-6474
1529-2401
1529-2401
DOI:10.1523/jneurosci.3576-12.2013