Survey of the Effect of Biotin on Glycemic Control and Plasma Lipid Concentrations in Type 1 Diabetic Patients in Kermanshah in Iran ( 2008 - 2009 )

• Published in: Oman medical journal 2013-05, Vol.28 (3), p.195-198
• Main Authors: Hemmati , Mitra, Abdolsalehei , Mohammadreza, Babaei , Homa
• Format: Article
• Language: English
• Subjects: BIOTIN; BLOOD SERUM; DIABETES; HbA1c; IRAN; LIPIDS; Original; PATIENTS; Serum lipid; THERAPY; Type one diabetes mellitus; إيران; البيوتين; الدهنيات; العلاج; المرضى; مرض السكر; مصل الدم
• ISSN: 1999-768X; 2070-5204
• DOI: 10.5001/omj.2013.53

Diabetes mellitus is the most common chronic endocrine disease worldwide. Intensive glycemic control plays an important role in decreasing morbidity and mortality rate of the disease. Preclinical studies have shown that biotin has an essential role in regulating blood glucose and serum lipid metabolism. This study aims to evaluate the effect of biotin on glycemic control and plasma lipids concentrations in type 1diabetic patients. This randomized double-blind placebo-controlled clinical trial study was conducted 70 type 1 diabetic patients with an age range 5-25 years old with poorly controlled (glycosylated hemoglobin ≥8%). Subjects were randomly allocated into two groups. In the intervention group biotin (40 microgram/kg) was administered plus daily insulin, while the control group received placebo plus daily insulin regimen for three months. Laboratory tests including glycosylated hemoglobin (HbA1c), fasting blood sugar and plasma lipids were measured at the base and after 3 months. In this study, seventy patients were evaluated, 35 were allocated to each group. There were no statistically significant differences between age, gender, duration of diabetes, BMI and BP between the two groups (p>0.05). HbA1c in the intervention (biotin) group was 9.84±1.80 at base and after 3 months treatment, it declined to 8.88±1.73 (p