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Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns
Particular cytokine gene polymorphisms are involved in the regulation of the antibody production. The consequences of already described IL-4, IL-10 and IL-13 gene polymorphisms on biological parameters and antibody levels were investigated among 576 mothers at delivery and their newborns in the cont...
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Published in: | BMC infectious diseases 2013-05, Vol.13 (1), p.215-215, Article 215 |
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creator | Lokossou, Adjimon Gatien Dechavanne, Célia Bouraïma, Aziz Courtin, David Le Port, Agnès Ladékpo, Rodolphe Noukpo, Julien Bonou, Désiré Ahouangninou, Claude Sabbagh, Audrey Fayomi, Benjamin Massougbodji, Achille Garcia, André Migot-Nabias, Florence |
description | Particular cytokine gene polymorphisms are involved in the regulation of the antibody production. The consequences of already described IL-4, IL-10 and IL-13 gene polymorphisms on biological parameters and antibody levels were investigated among 576 mothers at delivery and their newborns in the context of P. falciparum placental malaria infection.
The study took place in the semi-rural area of Tori-Bossito, in south-west Benin, where malaria is meso-endemic. Six biallelic polymorphisms were determined by quantitative PCR using TaqMan® Pre-Designed SNP Genotyping Assays, in IL-4 (rs2243250, rs2070874), IL-10 (rs1800896, rs1800871, rs1800872) and IL-13 (rs1800925) genes. Antibody responses directed to P. falciparum MSP-1, MSP-2, MSP-3, GLURP-R0, GLURP-R2 and AMA-1 recombinant proteins were determined by ELISA.
The maternal IL-4(-590)*T/IL-4(+33)*T haplotype (one or two copies) was associated with favorable maternal condition at delivery (high haemoglobin levels, absence of placental parasites) and one of its component, the IL-4(-590)TT genotype, was related to low IgG levels to MSP-1, MSP-2/3D7 and MSP-2/FC27. Inversely, the maternal IL-10(-1082)AA was positively associated with P. falciparum placenta infection at delivery. As a consequence, the IL-10(-819)*T allele (in CT and TT genotypes) as well as the IL-10(-1082)*A/IL-10(-819)*T/IL-10(-592)*A haplotype (one or two copies) in which it is included, were related to an increased risk for anaemia in newborns. The maternal IL-10(-1082)AA genotype was related to high IgG levels to MSP-2/3D7 and AMA-1 in mothers and newborns, respectively. The IL-13 gene polymorphism was only involved in the newborn's antibody response to AMA-1.
These data revealed that IL-4 and IL-10 maternal gene polymorphisms are likely to play a role in the regulation of biological parameters in pregnant women at delivery (anaemia, P. falciparum placenta infection) and in newborns (anaemia). Moreover, IL-4, IL-10 and IL-13 maternal gene polymorphisms were related to IgG responses to MSP-1, MSP-2/3D7 and MSP-2/FC27 in mothers as well as to AMA-1 in newborns. |
doi_str_mv | 10.1186/1471-2334-13-215 |
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The study took place in the semi-rural area of Tori-Bossito, in south-west Benin, where malaria is meso-endemic. Six biallelic polymorphisms were determined by quantitative PCR using TaqMan® Pre-Designed SNP Genotyping Assays, in IL-4 (rs2243250, rs2070874), IL-10 (rs1800896, rs1800871, rs1800872) and IL-13 (rs1800925) genes. Antibody responses directed to P. falciparum MSP-1, MSP-2, MSP-3, GLURP-R0, GLURP-R2 and AMA-1 recombinant proteins were determined by ELISA.
The maternal IL-4(-590)*T/IL-4(+33)*T haplotype (one or two copies) was associated with favorable maternal condition at delivery (high haemoglobin levels, absence of placental parasites) and one of its component, the IL-4(-590)TT genotype, was related to low IgG levels to MSP-1, MSP-2/3D7 and MSP-2/FC27. Inversely, the maternal IL-10(-1082)AA was positively associated with P. falciparum placenta infection at delivery. As a consequence, the IL-10(-819)*T allele (in CT and TT genotypes) as well as the IL-10(-1082)*A/IL-10(-819)*T/IL-10(-592)*A haplotype (one or two copies) in which it is included, were related to an increased risk for anaemia in newborns. The maternal IL-10(-1082)AA genotype was related to high IgG levels to MSP-2/3D7 and AMA-1 in mothers and newborns, respectively. The IL-13 gene polymorphism was only involved in the newborn's antibody response to AMA-1.
These data revealed that IL-4 and IL-10 maternal gene polymorphisms are likely to play a role in the regulation of biological parameters in pregnant women at delivery (anaemia, P. falciparum placenta infection) and in newborns (anaemia). Moreover, IL-4, IL-10 and IL-13 maternal gene polymorphisms were related to IgG responses to MSP-1, MSP-2/3D7 and MSP-2/FC27 in mothers as well as to AMA-1 in newborns.</description><identifier>ISSN: 1471-2334</identifier><identifier>EISSN: 1471-2334</identifier><identifier>DOI: 10.1186/1471-2334-13-215</identifier><identifier>PMID: 23668806</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adult ; Analysis ; Anemia ; Antibodies, Protozoan - blood ; Chi-Square Distribution ; Cohort Studies ; Female ; Genes ; Genetic aspects ; Genetic polymorphisms ; Haplotypes - genetics ; Haplotypes - immunology ; Host-Parasite Interactions ; Humans ; Immune response ; Immunoglobulin G - blood ; Immunoglobulin M - blood ; Infant, Newborn - immunology ; Infections ; Interleukin-10 - genetics ; Interleukin-4 - genetics ; Interleukins ; Malaria ; Malaria, Falciparum - genetics ; Malaria, Falciparum - immunology ; Plasmodium falciparum ; Plasmodium falciparum - genetics ; Plasmodium falciparum - immunology ; Polymorphism, Single Nucleotide ; Pregnancy ; Pregnancy Complications, Infectious - genetics ; Pregnancy Complications, Infectious - immunology ; Proteins ; Statistics, Nonparametric</subject><ispartof>BMC infectious diseases, 2013-05, Vol.13 (1), p.215-215, Article 215</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>2013 Lokossou et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Lokossou et al.; licensee BioMed Central Ltd. 2013 Lokossou et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b652t-17038b78d1dbe36f248cdb5b8d1ea8c31d72e30d2b68c9ee91e632157ea60b6d3</citedby><cites>FETCH-LOGICAL-b652t-17038b78d1dbe36f248cdb5b8d1ea8c31d72e30d2b68c9ee91e632157ea60b6d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679728/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1366719129?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23668806$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lokossou, Adjimon Gatien</creatorcontrib><creatorcontrib>Dechavanne, Célia</creatorcontrib><creatorcontrib>Bouraïma, Aziz</creatorcontrib><creatorcontrib>Courtin, David</creatorcontrib><creatorcontrib>Le Port, Agnès</creatorcontrib><creatorcontrib>Ladékpo, Rodolphe</creatorcontrib><creatorcontrib>Noukpo, Julien</creatorcontrib><creatorcontrib>Bonou, Désiré</creatorcontrib><creatorcontrib>Ahouangninou, Claude</creatorcontrib><creatorcontrib>Sabbagh, Audrey</creatorcontrib><creatorcontrib>Fayomi, Benjamin</creatorcontrib><creatorcontrib>Massougbodji, Achille</creatorcontrib><creatorcontrib>Garcia, André</creatorcontrib><creatorcontrib>Migot-Nabias, Florence</creatorcontrib><title>Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns</title><title>BMC infectious diseases</title><addtitle>BMC Infect Dis</addtitle><description>Particular cytokine gene polymorphisms are involved in the regulation of the antibody production. The consequences of already described IL-4, IL-10 and IL-13 gene polymorphisms on biological parameters and antibody levels were investigated among 576 mothers at delivery and their newborns in the context of P. falciparum placental malaria infection.
The study took place in the semi-rural area of Tori-Bossito, in south-west Benin, where malaria is meso-endemic. Six biallelic polymorphisms were determined by quantitative PCR using TaqMan® Pre-Designed SNP Genotyping Assays, in IL-4 (rs2243250, rs2070874), IL-10 (rs1800896, rs1800871, rs1800872) and IL-13 (rs1800925) genes. Antibody responses directed to P. falciparum MSP-1, MSP-2, MSP-3, GLURP-R0, GLURP-R2 and AMA-1 recombinant proteins were determined by ELISA.
The maternal IL-4(-590)*T/IL-4(+33)*T haplotype (one or two copies) was associated with favorable maternal condition at delivery (high haemoglobin levels, absence of placental parasites) and one of its component, the IL-4(-590)TT genotype, was related to low IgG levels to MSP-1, MSP-2/3D7 and MSP-2/FC27. Inversely, the maternal IL-10(-1082)AA was positively associated with P. falciparum placenta infection at delivery. As a consequence, the IL-10(-819)*T allele (in CT and TT genotypes) as well as the IL-10(-1082)*A/IL-10(-819)*T/IL-10(-592)*A haplotype (one or two copies) in which it is included, were related to an increased risk for anaemia in newborns. The maternal IL-10(-1082)AA genotype was related to high IgG levels to MSP-2/3D7 and AMA-1 in mothers and newborns, respectively. The IL-13 gene polymorphism was only involved in the newborn's antibody response to AMA-1.
These data revealed that IL-4 and IL-10 maternal gene polymorphisms are likely to play a role in the regulation of biological parameters in pregnant women at delivery (anaemia, P. falciparum placenta infection) and in newborns (anaemia). Moreover, IL-4, IL-10 and IL-13 maternal gene polymorphisms were related to IgG responses to MSP-1, MSP-2/3D7 and MSP-2/FC27 in mothers as well as to AMA-1 in newborns.</description><subject>Adult</subject><subject>Analysis</subject><subject>Anemia</subject><subject>Antibodies, Protozoan - blood</subject><subject>Chi-Square Distribution</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Haplotypes - genetics</subject><subject>Haplotypes - immunology</subject><subject>Host-Parasite Interactions</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin M - blood</subject><subject>Infant, Newborn - immunology</subject><subject>Infections</subject><subject>Interleukin-10 - genetics</subject><subject>Interleukin-4 - genetics</subject><subject>Interleukins</subject><subject>Malaria</subject><subject>Malaria, Falciparum - genetics</subject><subject>Malaria, Falciparum - immunology</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - genetics</subject><subject>Plasmodium falciparum - immunology</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - genetics</subject><subject>Pregnancy Complications, Infectious - immunology</subject><subject>Proteins</subject><subject>Statistics, Nonparametric</subject><issn>1471-2334</issn><issn>1471-2334</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNqNkk1v1DAQhiMEoqVw54QscaGHLHa8cewL0mpFYaWVivi6Wo4z2XWV2MF2KP33OLtl6aIiVT54NPPMq9E7k2UvCZ4RwtlbMq9IXlA6zwnNC1I-yk4Pqcd34pPsWQhXGJOKF-JpdlJQxjjH7DQbFiE4bVQ0ziLXotU6nyNlmykgGPUqgreqQ1s1dC7eDBDQtYlbZPp-tIA8hMHZkLLRoU8z1KpOm0H5sUfGot7FLfiw07NwXTtvw_PsSYICvLj9z7JvF--_Lj_m68sPq-VindesLGJOKkx5XfGGNDVQ1hZzrpu6rFMCFNeUNFUBFDdFzbgWAIIAo8mBChTDNWvoWfZurzuMdQ-NBhu96uTgTa_8jXTKyOOKNVu5cT8lZZWoCp4ElnuB2rj_CBxXtOvl5LicHJeEyjROUnlzO4Z3P0YIUfYmaOg6ZcGNIWFCCCwEKx6AsjKxWLCEvv4HvXLjtKcdxSoiSCH-UhvVgTS2dWlOPYnKRUnnDPNyR83uodJroDfaWWhNyh81nB81JCbCr7hRYwhy9eXzw9nL78cs3rPauxA8tAevCZbTud_n7qu7Sz40_Llv-htSCvej</recordid><startdate>20130513</startdate><enddate>20130513</enddate><creator>Lokossou, Adjimon Gatien</creator><creator>Dechavanne, Célia</creator><creator>Bouraïma, Aziz</creator><creator>Courtin, David</creator><creator>Le Port, Agnès</creator><creator>Ladékpo, Rodolphe</creator><creator>Noukpo, Julien</creator><creator>Bonou, Désiré</creator><creator>Ahouangninou, Claude</creator><creator>Sabbagh, Audrey</creator><creator>Fayomi, Benjamin</creator><creator>Massougbodji, Achille</creator><creator>Garcia, André</creator><creator>Migot-Nabias, Florence</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7T2</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7T5</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>5PM</scope></search><sort><creationdate>20130513</creationdate><title>Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns</title><author>Lokossou, Adjimon Gatien ; Dechavanne, Célia ; Bouraïma, Aziz ; Courtin, David ; Le Port, Agnès ; Ladékpo, Rodolphe ; Noukpo, Julien ; Bonou, Désiré ; Ahouangninou, Claude ; Sabbagh, Audrey ; Fayomi, Benjamin ; Massougbodji, Achille ; Garcia, André ; Migot-Nabias, Florence</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b652t-17038b78d1dbe36f248cdb5b8d1ea8c31d72e30d2b68c9ee91e632157ea60b6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Analysis</topic><topic>Anemia</topic><topic>Antibodies, Protozoan - 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The consequences of already described IL-4, IL-10 and IL-13 gene polymorphisms on biological parameters and antibody levels were investigated among 576 mothers at delivery and their newborns in the context of P. falciparum placental malaria infection.
The study took place in the semi-rural area of Tori-Bossito, in south-west Benin, where malaria is meso-endemic. Six biallelic polymorphisms were determined by quantitative PCR using TaqMan® Pre-Designed SNP Genotyping Assays, in IL-4 (rs2243250, rs2070874), IL-10 (rs1800896, rs1800871, rs1800872) and IL-13 (rs1800925) genes. Antibody responses directed to P. falciparum MSP-1, MSP-2, MSP-3, GLURP-R0, GLURP-R2 and AMA-1 recombinant proteins were determined by ELISA.
The maternal IL-4(-590)*T/IL-4(+33)*T haplotype (one or two copies) was associated with favorable maternal condition at delivery (high haemoglobin levels, absence of placental parasites) and one of its component, the IL-4(-590)TT genotype, was related to low IgG levels to MSP-1, MSP-2/3D7 and MSP-2/FC27. Inversely, the maternal IL-10(-1082)AA was positively associated with P. falciparum placenta infection at delivery. As a consequence, the IL-10(-819)*T allele (in CT and TT genotypes) as well as the IL-10(-1082)*A/IL-10(-819)*T/IL-10(-592)*A haplotype (one or two copies) in which it is included, were related to an increased risk for anaemia in newborns. The maternal IL-10(-1082)AA genotype was related to high IgG levels to MSP-2/3D7 and AMA-1 in mothers and newborns, respectively. The IL-13 gene polymorphism was only involved in the newborn's antibody response to AMA-1.
These data revealed that IL-4 and IL-10 maternal gene polymorphisms are likely to play a role in the regulation of biological parameters in pregnant women at delivery (anaemia, P. falciparum placenta infection) and in newborns (anaemia). Moreover, IL-4, IL-10 and IL-13 maternal gene polymorphisms were related to IgG responses to MSP-1, MSP-2/3D7 and MSP-2/FC27 in mothers as well as to AMA-1 in newborns.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>23668806</pmid><doi>10.1186/1471-2334-13-215</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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identifier | ISSN: 1471-2334 |
ispartof | BMC infectious diseases, 2013-05, Vol.13 (1), p.215-215, Article 215 |
issn | 1471-2334 1471-2334 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3679728 |
source | Publicly Available Content Database; PubMed Central |
subjects | Adult Analysis Anemia Antibodies, Protozoan - blood Chi-Square Distribution Cohort Studies Female Genes Genetic aspects Genetic polymorphisms Haplotypes - genetics Haplotypes - immunology Host-Parasite Interactions Humans Immune response Immunoglobulin G - blood Immunoglobulin M - blood Infant, Newborn - immunology Infections Interleukin-10 - genetics Interleukin-4 - genetics Interleukins Malaria Malaria, Falciparum - genetics Malaria, Falciparum - immunology Plasmodium falciparum Plasmodium falciparum - genetics Plasmodium falciparum - immunology Polymorphism, Single Nucleotide Pregnancy Pregnancy Complications, Infectious - genetics Pregnancy Complications, Infectious - immunology Proteins Statistics, Nonparametric |
title | Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns |
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