Transfer RNA modifications: nature's combinatorial chemistry playground

Following synthesis, tRNAs are peppered by numerous chemical modifications which may differentially affect a tRNA's structure and function. Although modifications affecting the business ends of a tRNA are predictably important for cell viability, a majority of modifications play more subtle str...

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Bibliographic Details
Published in:Wiley interdisciplinary reviews. RNA 2013-01, Vol.4 (1), p.35-48
Main Authors: Jackman, Jane E., Alfonzo, Juan D.
Format: Article
Language:English
Subjects:
Combinatorial chemistry
Humans
Protein Biosynthesis - genetics
Protein Biosynthesis - physiology
RNA editing
RNA modification
RNA processing
RNA Processing, Post-Transcriptional
RNA, Transfer - chemistry
RNA, Transfer - genetics
RNA, Transfer - metabolism
Structure-Activity Relationship
Structure-function relationships
Transfer RNA
tRNA
tRNA Ala
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Summary:Following synthesis, tRNAs are peppered by numerous chemical modifications which may differentially affect a tRNA's structure and function. Although modifications affecting the business ends of a tRNA are predictably important for cell viability, a majority of modifications play more subtle structural roles that can affect tRNA stability and folding. The current trend is that modifications act in concert and it is in the context of the specific sequence of a given tRNA that they impart their differing effects. Recent developments in the modification field have highlighted the diversity of modifications in tRNA. From these, the combinatorial nature of modifications in explaining previously described phenotypes derived from their absence has emerged as a growing theme. WIREs RNA 2013, 4:35–48. doi: 10.1002/wrna.1144 This article is categorized under: RNA Processing > RNA Editing and Modification RNA Processing > tRNA Processing
ISSN:1757-7004
1757-7012
DOI:10.1002/wrna.1144