Elevated Cardiac Troponin I and Relationship to Persistence of Electrocardiographic and Echocardiographic Abnormalities After Aneurysmal Subarachnoid Hemorrhage

BACKGROUND AND PURPOSE—Cardiac injury persistence after aneurysmal subarachnoid hemorrhage (aSAH) is not well described. We hypothesized that post-aSAH cardiac injury, detected by elevated cardiac troponin I (cTnI), is related to aSAH severity and associated with electrocardiographic and structural...

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Bibliographic Details
Published in:Stroke (1970) 2009-11, Vol.40 (11), p.3478-3484
Main Authors: Hravnak, Marilyn, Frangiskakis, J Michael, Crago, Elizabeth A, Chang, Yuefang, Tanabe, Masaki, Gorcsan, John, Horowitz, Michael B
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Biomarkers - blood
Echocardiography - methods
Electrocardiography - methods
Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care
Female
Humans
Intensive care medicine
Longitudinal Studies
Male
Medical sciences
Middle Aged
Neurology
Prospective Studies
Subarachnoid Hemorrhage - blood
Subarachnoid Hemorrhage - diagnostic imaging
Subarachnoid Hemorrhage - physiopathology
Troponin I - blood
Vascular diseases and vascular malformations of the nervous system
Young Adult
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Summary:BACKGROUND AND PURPOSE—Cardiac injury persistence after aneurysmal subarachnoid hemorrhage (aSAH) is not well described. We hypothesized that post-aSAH cardiac injury, detected by elevated cardiac troponin I (cTnI), is related to aSAH severity and associated with electrocardiographic and structural echocardiographic abnormalities that are persistent. METHODS—Prospective longitudinal study was conducted of patients with aSAH with Fisher grade ≥2 and/or Hunt/Hess grade ≥3. Serum cTnI was collected on Days 1 to 5; cohort dichotomized into peak cTnI ≥0.3 ng/mL (elevated) or cTnI
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.109.556753