Hippo inactivation feeds tumor-initiating cells

The Hippo pathway has emerged as a well-conserved kinase cascade controlling cell proliferation and survival and has recently gained much attention for its key activity as a tumor suppressor. In a study published in Cell, Cordenonsi and colleagues link TAZ, a downstream effector of the Hippo pathway...

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Bibliographic Details
Published in:Breast cancer research : BCR 2012-08, Vol.14 (4), p.318-318, Article 318
Main Authors: Duss, Stephan, Britschgi, Adrian, Bentires-Alj, Mohamed
Format: Article
Language:English
Subjects:
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Enzyme Activation
Female
Humans
Neoplastic Stem Cells - metabolism
Protein-Serine-Threonine Kinases - metabolism
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Summary:The Hippo pathway has emerged as a well-conserved kinase cascade controlling cell proliferation and survival and has recently gained much attention for its key activity as a tumor suppressor. In a study published in Cell, Cordenonsi and colleagues link TAZ, a downstream effector of the Hippo pathway, to attributes of putative breast cancer stem cells, epithelial-to-mesenchymal transition and cell polarity.
ISSN:1465-542X
1465-5411
1465-542X
DOI:10.1186/bcr3190