Clear cell variant of squamous cell carcinoma of skin: A report of a case

Clear cell squamous cell carcinoma (SCC) is a rare variant of SCC of skin in which ultraviolet radiation has been suggested as possible etiology. This case is that of a 62-year-old male concrete block maker/bricklayer who presented with a 6 months history of a non-healing ulcer on the left side of h...

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Bibliographic Details
Published in:Journal of oral and maxillofacial pathology : JOMFP 2013-01, Vol.17 (1), p.110-112
Main Authors: Lawal, Ahmed, Adisa, Akinyele, Olajide, Mofoluwaso, Olusanya, Adeola
Format: Article
Language:English
Subjects:
Case Report
Melanoma
Men
Nuclear radiation
Skin
Skin cancer
Squamous cell carcinoma
Tumors
Ulcers
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Summary:Clear cell squamous cell carcinoma (SCC) is a rare variant of SCC of skin in which ultraviolet radiation has been suggested as possible etiology. This case is that of a 62-year-old male concrete block maker/bricklayer who presented with a 6 months history of a non-healing ulcer on the left side of his face. Histology showed features of malignant epithelial neoplasm composed of islands of large oval to polyhedral malignant squamous cells with eosinophilic to amphophilic cytoplasm and vesicular nuclei and there were areas showing clear cell differentiation and isolated areas of keratin pearl formation. The lesion was also negative for periodic acid schiff, mucicarmine, and alcian blue stains but was strongly positive for AE1/AE3 (immuno-stain). This case showed an aggressive and bizarre clinical presentation but more report of cases are needed to have a better characterization of the clinical presentation and prognosis of this variant of SCC.
ISSN:0973-029X
1998-393X
DOI:10.4103/0973-029X.110697