Leukocyte-Mimicking Stem Cell Delivery via in Situ Coating of Cells with a Bioactive Hyperbranched Polyglycerol

Since stem cells emerged as a new generation of medicine, there are increasing efforts to deliver stem cells to a target tissue via intravascular injection. However, the therapeutic stem cells lack the capacity to detect and adhere to the target tissue. Therefore, this study presents synthesis of a...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2013-06, Vol.135 (24), p.8770-8773
Main Authors: Jeong, Jae Hyun, Schmidt, John J, Kohman, Richie E, Zill, Andrew T, DeVolder, Ross J, Smith, Cartney E, Lai, Mei-Hsiu, Shkumatov, Artem, Jensen, Tor W, Schook, Lawrence G, Zimmerman, Steven C, Kong, Hyunjoon
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Cell Adhesion
Endothelium, Vascular - injuries
Endothelium, Vascular - metabolism
Endovascular Procedures - methods
Glycerol - chemistry
Glycerol - metabolism
Humans
Injections
Leukocytes - cytology
Mesenchymal Stem Cell Transplantation - methods
Mesenchymal Stem Cells - cytology
Mesenchymal Stem Cells - metabolism
Peptides - chemistry
Peptides - metabolism
Polymers - chemistry
Polymers - metabolism
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Summary:Since stem cells emerged as a new generation of medicine, there are increasing efforts to deliver stem cells to a target tissue via intravascular injection. However, the therapeutic stem cells lack the capacity to detect and adhere to the target tissue. Therefore, this study presents synthesis of a bioactive hyperbranched polyglycerol (HPG) that can noninvasively associate with stem cells and further guide them to target sites, such as inflamed endothelium. The overall process is analogous to the way in which leukocytes are mobilized to the injured endothelium.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja400636d