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An Entry to Curcuphenol/Elvirol Core Structures via a Retro-Aldol Procedure

Curcuphenol/elvirol analogues, the naturally occurring bisabolane sesquiterpenes were prepared in six steps from alkyl α-tetralones employing an aromatization reaction of cyclic dienone precursors and olefination of the key aldehyde intermediates. The in vitro antifungal activities of 6a , 6b, 6d an...

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Bibliographic Details
Published in:Chemistry & biodiversity 2011-06, Vol.8 (6), p.1098-1111
Main Authors: Plano, María F., Labadie, Guillermo R., Jacob, Melissa R., Tekwani, Babu L., Cravero, Raquel M.
Format: Article
Language:English
Online Access:Get full text
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Summary:Curcuphenol/elvirol analogues, the naturally occurring bisabolane sesquiterpenes were prepared in six steps from alkyl α-tetralones employing an aromatization reaction of cyclic dienone precursors and olefination of the key aldehyde intermediates. The in vitro antifungal activities of 6a , 6b, 6d and 6g are also reported.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.201000160