Evaluation on the Pharmacological Effect of Traditional Chinese Medicine SiJunZiTang on Stress-Induced Peptic Ulcers

Purpose. To explore the effects of SiJunZiTang (SJZT) on central neurotransmitters and the inhibition of HCl hypersecretion, along with the role of the vagus nerve. From this, the effects of SJZT and its constituent ingredients on inhibiting stress-induced peptic ulcers will be determined. Methods....

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2013-01, Vol.2013 (2013), p.1-9
Main Authors: Hsieh, Chin-Lang, Lee, Chien-Ying, Lin, Po-Jung, Shih, Hung-Che, Chen, Chiu-Mei
Format: Article
Language:English
Subjects:
Acidity
Acids
Aspirin
Brain research
Chinese medicine
Chromatography
Constituents
Dopamine
Experiments
Gastrointestinal diseases
Good Manufacturing Practice
Herbal medicine
Laboratory animals
Medical research
Neurotransmitters
Peptic ulcers
Pharmaceuticals
Stomach
Stress
Traditional Chinese medicine
Ulcers
Vagus nerve
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Summary:Purpose. To explore the effects of SiJunZiTang (SJZT) on central neurotransmitters and the inhibition of HCl hypersecretion, along with the role of the vagus nerve. From this, the effects of SJZT and its constituent ingredients on inhibiting stress-induced peptic ulcers will be determined. Methods. Methods used to determine SJZT's effectiveness included (1) measuring the antipeptic ulcer effects of varying combinations of the constituents of SJZT; (2) evaluations of monoamine (MA) level in the brain; and (3) measuring the effects of longer-term SJZT treatment. Results. Comparing the control and experimental groups where the rats’ vagus nerves were not cut after taking SJZT orally (500 mg/kg and 1000 mg/kg), the volume of enterogastric juice, free HCl and total acidity all reduce dose-dependently. The group administered SJZT at 1000 mg/kg showed significant reductions (P
ISSN:1741-427X
1741-4288
DOI:10.1155/2013/186076