Sleep and immune function: glial contributions and consequences of aging

Highlights • Microglia modulate NREMS and slow wave activity via production of immunomodulators. • Astrocytic gliotransmission mediates NREMS and sleep pressure. • ATP (via P2X7R) and adenosine (via A1R) may be effectors of glial sleep regulation. • Aging is associated with poor sleep quality and ch...

Full description

Saved in:
Bibliographic Details
Published in:Current opinion in neurobiology 2013-10, Vol.23 (5), p.806-811
Main Authors: Ingiosi, Ashley M, Opp, Mark R, Krueger, James M
Format: Article
Language:English
Subjects:
Aging - immunology
Animals
Brain - immunology
Humans
Immunity, Innate - immunology
Neuroglia - immunology
Neurology
Psychiatry
Sleep - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Microglia modulate NREMS and slow wave activity via production of immunomodulators. • Astrocytic gliotransmission mediates NREMS and sleep pressure. • ATP (via P2X7R) and adenosine (via A1R) may be effectors of glial sleep regulation. • Aging is associated with poor sleep quality and chronic, low-grade inflammation. • Primed microglia and activated astrocytes contribute to changes of the aging CNS.
ISSN:0959-4388
1873-6882
DOI:10.1016/j.conb.2013.02.003