Use of Antistaphylococcal β-Lactams to Increase Daptomycin Activity in Eradicating Persistent Bacteremia Due to Methicillin-Resistant Staphylococcus aureus: Role of Enhanced Daptomycin Binding

We used daptomycin plsu antistaphylococcal β-lactams (ASBL) to clear refractory MRSA bacteremia. In vitro studies showed enhanced daptomycin bactericidal activity, increased membrane daptomycin binding, and decrease in positive surface change induced by ASBLs against daptomycin non-susceptible MRSA....

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Bibliographic Details
Published in:Clinical infectious diseases 2011-07, Vol.53 (2), p.158-163
Main Authors: Dhand, Abhay, Bayer, Arnold S., Pogliano, Joseph, Yang, Soo-Jin, Bolaris, Michael, Nizet, Victor, Wang, Guiquing, Sakoulas, George
Format: Article
Language:English
Subjects:
Adult
Aged, 80 and over
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteremia
Bacteremia - drug therapy
Bacteremia - microbiology
Bacterial diseases
Bacterial sepsis
beta-Lactams - administration & dosage
beta-Lactams - pharmacology
Biological and medical sciences
BRIEF REPORTS
Cell Membrane - chemistry
Cell Membrane - physiology
Cubism
Daptomycin - administration & dosage
Daptomycin - pharmacology
Drug Resistance, Bacterial
Drug Therapy, Combination - methods
Endocarditis
Female
Human bacterial diseases
Humans
Infections
Infectious diseases
Male
Medical sciences
Membrane Potentials - drug effects
Methicillin resistant staphylococcus aureus
Methicillin-Resistant Staphylococcus aureus - drug effects
Methicillin-Resistant Staphylococcus aureus - isolation & purification
Microbial Sensitivity Tests
Middle Aged
Pharmaceutical preparations
Pharmacology. Drug treatments
Relapse
Staphylococcal infections, streptococcal infections, pneumococcal infections
Staphylococcus
Staphylococcus aureus
Treatment Outcome
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Summary:We used daptomycin plsu antistaphylococcal β-lactams (ASBL) to clear refractory MRSA bacteremia. In vitro studies showed enhanced daptomycin bactericidal activity, increased membrane daptomycin binding, and decrease in positive surface change induced by ASBLs against daptomycin non-susceptible MRSA. Addition of ASBLs to daptomycin may be of benefit in refractory MRSA bacteremia. (Although the official designation is "daptomycin nonsusceptibility," we will use the term "daptomycin-resistance" in this paper for facility of presentation.)
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/cir340