Phospholipase D1 Has a Pivotal Role in Interleukin-1β-Driven Chronic Autoimmune Arthritis through Regulation of NF-κB, Hypoxia-Inducible Factor 1α, and FoxO3a

• Published in: Molecular and Cellular Biology 2013-07, Vol.33 (14), p.2760-2772
• Main Authors: Kang, Dong Woo, Park, Mi-Kyung, Oh, Hye-Joa, Lee, Dong-Gun, Park, Sung-Hwan, Choi, Kang-Yell, Cho, Mi-La, Min, Do Sik
• Format: Article
• Language: English
• Subjects: Angiogenic Proteins - genetics; Angiogenic Proteins - metabolism; Animals; Arthritis, Rheumatoid - enzymology; Arthritis, Rheumatoid - pathology; Cell Cycle Checkpoints; Cell Movement; Cell Proliferation; Cells, Cultured; Chronic Disease; Enzyme Induction; Enzyme Inhibitors - pharmacology; Fibroblasts - drug effects; Fibroblasts - enzymology; Forkhead Box Protein O3; Forkhead Transcription Factors - metabolism; Human Umbilical Vein Endothelial Cells - drug effects; Human Umbilical Vein Endothelial Cells - physiology; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Inflammation Mediators - metabolism; Interleukin 1 Receptor Antagonist Protein - deficiency; Interleukin 1 Receptor Antagonist Protein - genetics; Interleukin-1beta - physiology; Joint Capsule - enzymology; Joint Capsule - pathology; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Knockout; Neovascularization, Pathologic - enzymology; NF-kappa B - metabolism; Phospholipase D - antagonists & inhibitors; Phospholipase D - physiology; Phosphorylation; Promoter Regions, Genetic; Protein Processing, Post-Translational; TNF Receptor-Associated Factor 6 - metabolism; Transcriptional Activation
• ISSN: 0270-7306; 1098-5549; 1098-5549
• DOI: 10.1128/MCB.01519-12

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