Maternal microchimerism protects against the development of asthma

• Published in: Journal of allergy and clinical immunology 2013-07, Vol.132 (1), p.39-44.e4
• Main Authors: Thompson, Emma E., PhD, Myers, Rachel A., PhD, Du, Gaixin, MS, Aydelotte, Tessa M., BA, Tisler, Christopher J., MS, Stern, Debra A., MS, Evans, Michael D., MS, Graves, Penelope E., ScD, Jackson, Daniel J., MD, Martinez, Fernando D., MD, Gern, James E., MD, Wright, Anne L., PhD, Lemanske, Robert F., MD, Ober, Carole, PhD
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age; Allergy and Immunology; Asthma; Asthma - genetics; Asthma - prevention & control; Biological and medical sciences; Child; Child, Preschool; Children & youth; Chimerism; Cohort Studies; Colleges & universities; Deoxyribonucleic acid; Disease; DNA; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Genetic testing; Humans; Infant; Logistic Models; Male; maternal; Medical sciences; microchimerism; Mothers; Pregnancy; Risk factors; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Womens health
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/j.jaci.2012.12.1575

Background Maternal asthma and child’s sex are among the most significant and reproducible risk factors for the development of asthma. Although the mechanisms for these effects are unknown, they likely involve nonclassical genetic mechanisms. One such mechanism could involve the transfer and persistence of maternal cells to her offspring, a common occurrence known as maternal microchimerism (MMc). MMc has been associated with many autoimmune diseases but has not been investigated for a role in asthma or allergic disease. Objective We hypothesized that some of the observed risks for asthma may be due to different rates of transmission or persistence of maternal cells to children of mothers with asthma compared with children of mothers without asthma, or to sons compared with daughters. We further hypothesized that rates of MMc differ between children with and without asthma. Methods We tested these hypotheses in 317 subjects from 3 independent cohorts by using a real-time quantitative PCR assay to detect a noninherited HLA allele in the child. Results MMc was detected in 20.5% of the subjects (range 16.8%-27.1% in the 3 cohorts). We observed lower rates of asthma among MMc-positive subjects than among MMc-negative subjects (odds ratio, 0.38; 95% CI, 0.19-0.79; P  = .029). Neither maternal asthma nor sex of the child was a significant predictor of MMc in the child ( P  = .81 and .15, respectively). Conclusions Our results suggest for the first time that MMc may protect against the development of asthma.