The ultra-early protective effect of ulinastatin on rabbit acute lung injury induced by paraquat

To study ultra-early pathophysiological changes of rabbit acute lung injury (ALI) caused by paraquat (PQ) and discuss the ultra-early protective effect of ulinastatin on rabbit ALI due to PQ. 30 New Zealand white rabbits were randomly divided into a control group, a paraquat group and an ulinastatin...

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Published in:BMC emergency medicine 2013-07, Vol.13 Suppl 1 (S1), p.S7-S7, Article S7
Main Authors: Song, Zujun, Chen, Gaofei, Lin, Gang, Jia, Chiyu, Cao, Jianxia, Ao, Guokun
Format: Article
Language:English
Subjects:
Acute Lung Injury - chemically induced
Acute Lung Injury - drug therapy
Acute Lung Injury - pathology
Acute Lung Injury - physiopathology
Analysis of Variance
Animals
Capillaries - pathology
Female
Glycoproteins - therapeutic use
Lung - blood supply
Lung - pathology
Lung - ultrastructure
Male
Multidetector Computed Tomography
Paraquat
Proceedings
Rabbits
Regional Blood Flow
Time Factors
Trypsin Inhibitors - therapeutic use
Vascular Endothelial Growth Factor A - blood
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Summary:To study ultra-early pathophysiological changes of rabbit acute lung injury (ALI) caused by paraquat (PQ) and discuss the ultra-early protective effect of ulinastatin on rabbit ALI due to PQ. 30 New Zealand white rabbits were randomly divided into a control group, a paraquat group and an ulinastatin intervention group with 10 rabbits in each group. For paraquat group and intervention group a single dose of paraquat (35 mg/kg) was injected intraperitoneally to establish rabbit models of ALI. The control group was injected an equal volume of saline. The intervention group was treated with 100 Ku/kg ulinastatin immediately after the establishment of the ALI model. The respective experimental groups underwent 320-slice CT perfusion scan of pleural at 2h, 4h and 6h time point after modeling to get CTP (CT Perfusion) images and related parameters. 2 mL blood was collected in the marginal ear vein to determine the mass concentration of the vascular endothelial growth factor (VEGF). The animals were killed by air embolism after 6h and lung tissue was taken for pathology observation. The reginal blood flow (rBF) and reginal blood volume (rBV) of paraquat group at 2,4,6 h time point were significantly (P
ISSN:1471-227X
1471-227X
DOI:10.1186/1471-227X-13-S1-S7