The use of HE4, CA125 and CA72-4 biomarkers for differential diagnosis between ovarian endometrioma and epithelial ovarian cancer

Endometriosis is frequently associated with high levels of CA125. This marker is therefore not useful for discriminating ovarian endometrioma from ovarian malignancy. The aim of this study was to establish a panel of complementary biomarkers that could be helpful in the differential diagnosis betwee...

Full description

Saved in:
Bibliographic Details
Published in:Journal of ovarian research 2013-07, Vol.6 (1), p.44-44, Article 44
Main Authors: Anastasi, Emanuela, Granato, Teresa, Falzarano, Renato, Storelli, Paola, Ticino, Adele, Frati, Luigi, Panici, Pierluigi Benedetti, Porpora, Maria Grazia
Format: Article
Language:English
Subjects:
Biological markers
Cancer
Diagnosis
Genetic aspects
Methods
Ovarian cancer
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Endometriosis is frequently associated with high levels of CA125. This marker is therefore not useful for discriminating ovarian endometrioma from ovarian malignancy. The aim of this study was to establish a panel of complementary biomarkers that could be helpful in the differential diagnosis between ovarian endometriosis or other ovarian benign masses and ovarian cancer. Blood samples from 50 healthy women, 17 patients with benign ovarian tumors, 57 patients with ovarian endometrioma and 39 patients with ovarian cancer were analyzed and serum values were measured for the following biomarkers: CA125, HE4 and CA72-4. Serum CA125 concentration was elevated in both patients with ovarian endometriosis and ovarian cancer but not in patients with other benign ovarian masses. HE4 was never increased in patients with endometriosis or benign masses whereas it was significantly higher in all patients with ovarian cancer (p 
ISSN:1757-2215
1757-2215
DOI:10.1186/1757-2215-6-44